COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?

From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existen...

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Autores principales: Rizzo, Paola, Vieceli Dalla Sega, Francesco, Fortini, Francesca, Marracino, Luisa, Rapezzi, Claudio, Ferrari, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144545/
https://www.ncbi.nlm.nih.gov/pubmed/32274570
http://dx.doi.org/10.1007/s00395-020-0791-5
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author Rizzo, Paola
Vieceli Dalla Sega, Francesco
Fortini, Francesca
Marracino, Luisa
Rapezzi, Claudio
Ferrari, Roberto
author_facet Rizzo, Paola
Vieceli Dalla Sega, Francesco
Fortini, Francesca
Marracino, Luisa
Rapezzi, Claudio
Ferrari, Roberto
author_sort Rizzo, Paola
collection PubMed
description From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease.
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spelling pubmed-71445452020-04-09 COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm? Rizzo, Paola Vieceli Dalla Sega, Francesco Fortini, Francesca Marracino, Luisa Rapezzi, Claudio Ferrari, Roberto Basic Res Cardiol Editorial From January 2020, coronavirus disease (COVID-19) originated in China has spread around the world. The disease is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The presence of myocarditis, cardiac arrest, and acute heart failure in COVID-19 patients suggests the existence of a relationship between SARS-CoV-2 infection and cardiac disease. The Notch signalling is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. In this report we discuss the possibility to target Notch signalling to prevent SARS-CoV-2 infection and interfere with the progression of COVID-19- associated heart and lungs disease. Springer Berlin Heidelberg 2020-04-09 2020 /pmc/articles/PMC7144545/ /pubmed/32274570 http://dx.doi.org/10.1007/s00395-020-0791-5 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Editorial
Rizzo, Paola
Vieceli Dalla Sega, Francesco
Fortini, Francesca
Marracino, Luisa
Rapezzi, Claudio
Ferrari, Roberto
COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
title COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
title_full COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
title_fullStr COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
title_full_unstemmed COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
title_short COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?
title_sort covid-19 in the heart and the lungs: could we “notch” the inflammatory storm?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144545/
https://www.ncbi.nlm.nih.gov/pubmed/32274570
http://dx.doi.org/10.1007/s00395-020-0791-5
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