Cargando…
The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144559/ https://www.ncbi.nlm.nih.gov/pubmed/32197531 http://dx.doi.org/10.3390/molecules25061392 |
_version_ | 1783519858165547008 |
---|---|
author | Pu, Shichen Liu, Yumin Liang, Shan Liu, Pin Qian, Hongmei Wu, Qian Wang, Yuliang |
author_facet | Pu, Shichen Liu, Yumin Liang, Shan Liu, Pin Qian, Hongmei Wu, Qian Wang, Yuliang |
author_sort | Pu, Shichen |
collection | PubMed |
description | Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed the metabolic changes using gas chromatography time-of-flight mass spectrometry (GC/TOF MS). Compared with the model group, a variety of different metabolites of artesunate and ursolic acid, alone or in combination, were found and confirmed. These differential metabolites, including fatty acids, lipids, and amino acids, were involved in lipid metabolism, energy metabolism, and amino acid metabolism. It indicated that two agents of artesunate and ursolic acid could attenuate or normalize the metabolic transformation on these metabolic pathways. |
format | Online Article Text |
id | pubmed-7144559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71445592020-04-15 The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet Pu, Shichen Liu, Yumin Liang, Shan Liu, Pin Qian, Hongmei Wu, Qian Wang, Yuliang Molecules Article Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed the metabolic changes using gas chromatography time-of-flight mass spectrometry (GC/TOF MS). Compared with the model group, a variety of different metabolites of artesunate and ursolic acid, alone or in combination, were found and confirmed. These differential metabolites, including fatty acids, lipids, and amino acids, were involved in lipid metabolism, energy metabolism, and amino acid metabolism. It indicated that two agents of artesunate and ursolic acid could attenuate or normalize the metabolic transformation on these metabolic pathways. MDPI 2020-03-18 /pmc/articles/PMC7144559/ /pubmed/32197531 http://dx.doi.org/10.3390/molecules25061392 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pu, Shichen Liu, Yumin Liang, Shan Liu, Pin Qian, Hongmei Wu, Qian Wang, Yuliang The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet |
title | The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet |
title_full | The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet |
title_fullStr | The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet |
title_full_unstemmed | The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet |
title_short | The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet |
title_sort | metabolic changes of artesunate and ursolic acid on syrian golden hamsters fed with the high-fat diet |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144559/ https://www.ncbi.nlm.nih.gov/pubmed/32197531 http://dx.doi.org/10.3390/molecules25061392 |
work_keys_str_mv | AT pushichen themetabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT liuyumin themetabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT liangshan themetabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT liupin themetabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT qianhongmei themetabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT wuqian themetabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT wangyuliang themetabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT pushichen metabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT liuyumin metabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT liangshan metabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT liupin metabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT qianhongmei metabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT wuqian metabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet AT wangyuliang metabolicchangesofartesunateandursolicacidonsyriangoldenhamstersfedwiththehighfatdiet |