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The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet

Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed...

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Autores principales: Pu, Shichen, Liu, Yumin, Liang, Shan, Liu, Pin, Qian, Hongmei, Wu, Qian, Wang, Yuliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144559/
https://www.ncbi.nlm.nih.gov/pubmed/32197531
http://dx.doi.org/10.3390/molecules25061392
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author Pu, Shichen
Liu, Yumin
Liang, Shan
Liu, Pin
Qian, Hongmei
Wu, Qian
Wang, Yuliang
author_facet Pu, Shichen
Liu, Yumin
Liang, Shan
Liu, Pin
Qian, Hongmei
Wu, Qian
Wang, Yuliang
author_sort Pu, Shichen
collection PubMed
description Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed the metabolic changes using gas chromatography time-of-flight mass spectrometry (GC/TOF MS). Compared with the model group, a variety of different metabolites of artesunate and ursolic acid, alone or in combination, were found and confirmed. These differential metabolites, including fatty acids, lipids, and amino acids, were involved in lipid metabolism, energy metabolism, and amino acid metabolism. It indicated that two agents of artesunate and ursolic acid could attenuate or normalize the metabolic transformation on these metabolic pathways.
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spelling pubmed-71445592020-04-15 The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet Pu, Shichen Liu, Yumin Liang, Shan Liu, Pin Qian, Hongmei Wu, Qian Wang, Yuliang Molecules Article Artesunate was well known as an antimalarial drug. Our previous research found that it has hypolipidemia effects in rabbits fed with a high-fat diet, especially combined with ursolic acid. In this study, we reconfirmed the lipid-lowering effect of artesunate and ursolic acid in hamsters and analyzed the metabolic changes using gas chromatography time-of-flight mass spectrometry (GC/TOF MS). Compared with the model group, a variety of different metabolites of artesunate and ursolic acid, alone or in combination, were found and confirmed. These differential metabolites, including fatty acids, lipids, and amino acids, were involved in lipid metabolism, energy metabolism, and amino acid metabolism. It indicated that two agents of artesunate and ursolic acid could attenuate or normalize the metabolic transformation on these metabolic pathways. MDPI 2020-03-18 /pmc/articles/PMC7144559/ /pubmed/32197531 http://dx.doi.org/10.3390/molecules25061392 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pu, Shichen
Liu, Yumin
Liang, Shan
Liu, Pin
Qian, Hongmei
Wu, Qian
Wang, Yuliang
The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
title The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
title_full The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
title_fullStr The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
title_full_unstemmed The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
title_short The Metabolic Changes of Artesunate and Ursolic Acid on Syrian Golden Hamsters Fed with the High-Fat Diet
title_sort metabolic changes of artesunate and ursolic acid on syrian golden hamsters fed with the high-fat diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144559/
https://www.ncbi.nlm.nih.gov/pubmed/32197531
http://dx.doi.org/10.3390/molecules25061392
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