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Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography
BACKGROUND/AIM: The global problems of chronic liver disease and non‐alcoholic fatty liver disease (NAFLD) are increasing. We examined the prevalence of NAFLD and significant liver stiffness in an asymptomatic population and identified the predictors of significant fibrosis in NAFLD. METHOD: We pros...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Publishing Asia Pty Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144791/ https://www.ncbi.nlm.nih.gov/pubmed/32280772 http://dx.doi.org/10.1002/jgh3.12252 |
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author | Teeratorn, Nicha Piyachaturawat, Panida Thanapirom, Kessarin Chaiteerakij, Roongruedee Sonsiri, Kanokwan Komolmit, Piyawat Tangkijvanich, Pisit Rerknimitr, Rungsun Adams, Leon Treeprasertsuk, Sombat |
author_facet | Teeratorn, Nicha Piyachaturawat, Panida Thanapirom, Kessarin Chaiteerakij, Roongruedee Sonsiri, Kanokwan Komolmit, Piyawat Tangkijvanich, Pisit Rerknimitr, Rungsun Adams, Leon Treeprasertsuk, Sombat |
author_sort | Teeratorn, Nicha |
collection | PubMed |
description | BACKGROUND/AIM: The global problems of chronic liver disease and non‐alcoholic fatty liver disease (NAFLD) are increasing. We examined the prevalence of NAFLD and significant liver stiffness in an asymptomatic population and identified the predictors of significant fibrosis in NAFLD. METHOD: We prospectively enrolled Thai subjects, aged 18–80 years, from four regions (Bangkok, Central, North, South) of Thailand from March 2013 to November 2016. All participants underwent controlled attenuation parameter (CAP) measurement for liver fat quantification and transient elastography (TE) for liver stiffness measurement (LSM). NAFLD was defined as liver fat ≥10% (CAP ≥ 306 dB/m). Of 1145 participants, 782 (68.3%) were eligible for analysis. RESULT: The mean age ± standard deviation (SD) was 53.1 ± 4.6 years, and 71.6% were female. The mean ± SD values of CAP and LSM of the overall cohort were 241.9 ± 61.4 dB/m and 5.5 ± 3.8 kPa, respectively. The prevalence of NAFLD was 18.0%, whereas 5.4% of the cohort had nonobese NAFLD (BMI < 25 kg/m(2)), and 2.8% had lean NAFLD (BMI < 23 kg/m(2)). The prevalence of significant liver fibrosis (≥F2) in NAFLD subjects was 18.4%. On multivariate analysis, the degree of significant fibrosis in NAFLD was significantly associated with male gender and a history of dyslipidemia. CONCLUSION: NAFLD with significant fibrosis (≥F2) is prevalent in asymptomatic populations. The predictors of significant fibrosis in NAFLD were male gender and dyslipidemia. Screening for NAFLD using CAP/TE in asymptomatic populations should be considered in hospitals with available facilities. |
format | Online Article Text |
id | pubmed-7144791 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wiley Publishing Asia Pty Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-71447912020-04-10 Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography Teeratorn, Nicha Piyachaturawat, Panida Thanapirom, Kessarin Chaiteerakij, Roongruedee Sonsiri, Kanokwan Komolmit, Piyawat Tangkijvanich, Pisit Rerknimitr, Rungsun Adams, Leon Treeprasertsuk, Sombat JGH Open Original Articles BACKGROUND/AIM: The global problems of chronic liver disease and non‐alcoholic fatty liver disease (NAFLD) are increasing. We examined the prevalence of NAFLD and significant liver stiffness in an asymptomatic population and identified the predictors of significant fibrosis in NAFLD. METHOD: We prospectively enrolled Thai subjects, aged 18–80 years, from four regions (Bangkok, Central, North, South) of Thailand from March 2013 to November 2016. All participants underwent controlled attenuation parameter (CAP) measurement for liver fat quantification and transient elastography (TE) for liver stiffness measurement (LSM). NAFLD was defined as liver fat ≥10% (CAP ≥ 306 dB/m). Of 1145 participants, 782 (68.3%) were eligible for analysis. RESULT: The mean age ± standard deviation (SD) was 53.1 ± 4.6 years, and 71.6% were female. The mean ± SD values of CAP and LSM of the overall cohort were 241.9 ± 61.4 dB/m and 5.5 ± 3.8 kPa, respectively. The prevalence of NAFLD was 18.0%, whereas 5.4% of the cohort had nonobese NAFLD (BMI < 25 kg/m(2)), and 2.8% had lean NAFLD (BMI < 23 kg/m(2)). The prevalence of significant liver fibrosis (≥F2) in NAFLD subjects was 18.4%. On multivariate analysis, the degree of significant fibrosis in NAFLD was significantly associated with male gender and a history of dyslipidemia. CONCLUSION: NAFLD with significant fibrosis (≥F2) is prevalent in asymptomatic populations. The predictors of significant fibrosis in NAFLD were male gender and dyslipidemia. Screening for NAFLD using CAP/TE in asymptomatic populations should be considered in hospitals with available facilities. Wiley Publishing Asia Pty Ltd 2019-09-04 /pmc/articles/PMC7144791/ /pubmed/32280772 http://dx.doi.org/10.1002/jgh3.12252 Text en © 2019 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Articles Teeratorn, Nicha Piyachaturawat, Panida Thanapirom, Kessarin Chaiteerakij, Roongruedee Sonsiri, Kanokwan Komolmit, Piyawat Tangkijvanich, Pisit Rerknimitr, Rungsun Adams, Leon Treeprasertsuk, Sombat Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography |
title | Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography |
title_full | Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography |
title_fullStr | Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography |
title_full_unstemmed | Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography |
title_short | Screening for non‐alcoholic fatty liver disease in community setting: A cohort study using controlled attenuation parameter‐transient elastography |
title_sort | screening for non‐alcoholic fatty liver disease in community setting: a cohort study using controlled attenuation parameter‐transient elastography |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144791/ https://www.ncbi.nlm.nih.gov/pubmed/32280772 http://dx.doi.org/10.1002/jgh3.12252 |
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