Enhancer occlusion transcripts regulate the activity of human enhancer domains via transcriptional interference: a computational perspective

Analysis of ENCODE long RNA-Seq and ChIP-seq (Chromatin Immunoprecipitation Sequencing) datasets for HepG2 and HeLa cell lines uncovered 1647 and 1958 transcripts that interfere with transcription factor binding to human enhancer domains. TFBSs (Transcription Factor Binding Sites) intersected by the...

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Detalles Bibliográficos
Autores principales: Pande, Amit, Makalowski, Wojciech, Brosius, Jürgen, Raabe, Carsten A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144904/
https://www.ncbi.nlm.nih.gov/pubmed/32133533
http://dx.doi.org/10.1093/nar/gkaa026

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