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Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells

The CFTR gene lies within an invariant topologically associated domain (TAD) demarcated by CTCF and cohesin, but shows cell-type specific control mechanisms utilizing different cis-regulatory elements (CRE) within the TAD. Within the respiratory epithelium, more than one cell type expresses CFTR and...

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Detalles Bibliográficos
Autores principales:	NandyMazumdar, Monali, Yin, Shiyi, Paranjapye, Alekh, Kerschner, Jenny L, Swahn, Hannah, Ge, Alex, Leir, Shih-Hsing, Harris, Ann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144911/ https://www.ncbi.nlm.nih.gov/pubmed/32095812 http://dx.doi.org/10.1093/nar/gkaa089

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