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Thrombin binding aptamer G-quadruplex stabilized by pyrene-modified nucleotides

Guanine-rich regions of the human genome can adopt non-canonical secondary structures. Their role in regulating gene expression has turned them into promising targets for therapeutic intervention. Ligands based on polyaromatic moieties are especially suitable for targeting G-quadruplexes utilizing t...

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Detalles Bibliográficos
Autores principales:	Kovačič, Matic, Podbevšek, Peter, Tateishi-Karimata, Hisae, Takahashi, Shuntaro, Sugimoto, Naoki, Plavec, Janez
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144916/ https://www.ncbi.nlm.nih.gov/pubmed/32095808 http://dx.doi.org/10.1093/nar/gkaa118

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