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Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system
During non-homologous DNA end joining (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequisite for ligation by XRCC4:Ligase IV (X4L4). This physical juxtaposition of DNA ends is called NHEJ synapsis. In addition to the key NHEJ synapsis proteins, Ku, X4L4, and XLF, it has b...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144918/ https://www.ncbi.nlm.nih.gov/pubmed/32052035 http://dx.doi.org/10.1093/nar/gkaa094 |