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Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system

During non-homologous DNA end joining (NHEJ), bringing two broken dsDNA ends into proximity is an essential prerequisite for ligation by XRCC4:Ligase IV (X4L4). This physical juxtaposition of DNA ends is called NHEJ synapsis. In addition to the key NHEJ synapsis proteins, Ku, X4L4, and XLF, it has b...

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Detalles Bibliográficos
Autores principales: Zhao, Bailin, Watanabe, Go, Lieber, Michael R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144918/
https://www.ncbi.nlm.nih.gov/pubmed/32052035
http://dx.doi.org/10.1093/nar/gkaa094

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