Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes

Reverse transcription (RT) of RNA templates containing RNA modifications leads to synthesis of cDNA containing information on the modification in the form of misincorporation, arrest, or nucleotide skipping events. A compilation of such events from multiple cDNAs represents an RT-signature that is t...

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Detalles Bibliográficos
Autores principales: Werner, Stephan, Schmidt, Lukas, Marchand, Virginie, Kemmer, Thomas, Falschlunger, Christoph, Sednev, Maksim V, Bec, Guillaume, Ennifar, Eric, Höbartner, Claudia, Micura, Ronald, Motorin, Yuri, Hildebrandt, Andreas, Helm, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144921/
https://www.ncbi.nlm.nih.gov/pubmed/32095818
http://dx.doi.org/10.1093/nar/gkaa113

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