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Proteotoxic stress promotes entrapment of ribosomes and misfolded proteins in a shared cytosolic compartment
Cells continuously monitor protein synthesis to prevent accumulation of aberrant polypeptides. Insufficient capacity of cellular degradative systems, chaperone shortage or high levels of mistranslation by ribosomes can result in proteotoxic stress and endanger proteostasis. One of the least explored...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144922/ https://www.ncbi.nlm.nih.gov/pubmed/32030400 http://dx.doi.org/10.1093/nar/gkaa068 |