Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2

Some transcription factors that specifically bind double-stranded DNA appear to also function as RNA-binding proteins. Here, we demonstrate that the transcription factor Sox2 is able to directly bind RNA in vitro as well as in mouse and human cells. Sox2 targets RNA via a 60-amino-acid RNA binding m...

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Detalles Bibliográficos
Autores principales: Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144947/
https://www.ncbi.nlm.nih.gov/pubmed/32016422
http://dx.doi.org/10.1093/nar/gkaa067

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