Cargando…

Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation

Controlled oxygenated rewarming (COR) has been shown to be a feasible and safe method in clinical practice and to reduce peak serum transaminases after liver transplantation. This study aimed to demonstrate further clinical experience of this method of now 18 clinical liver transplantations utilizin...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoyer, Dieter P., Benkö, Tamas, Manka, Paul, von Horn, Charlotte, Treckmann, Juergen W., Paul, Andreas, Minor, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145002/
https://www.ncbi.nlm.nih.gov/pubmed/32309628
http://dx.doi.org/10.1097/TXD.0000000000000987
_version_ 1783519924015071232
author Hoyer, Dieter P.
Benkö, Tamas
Manka, Paul
von Horn, Charlotte
Treckmann, Juergen W.
Paul, Andreas
Minor, Thomas
author_facet Hoyer, Dieter P.
Benkö, Tamas
Manka, Paul
von Horn, Charlotte
Treckmann, Juergen W.
Paul, Andreas
Minor, Thomas
author_sort Hoyer, Dieter P.
collection PubMed
description Controlled oxygenated rewarming (COR) has been shown to be a feasible and safe method in clinical practice and to reduce peak serum transaminases after liver transplantation. This study aimed to demonstrate further clinical experience of this method of now 18 clinical liver transplantations utilizing COR and demonstrate the long-term results. METHODS. In this extended series of 18 patients, cold-stored livers were subjected to machine-assisted slow COR for ≈120 minutes before transplantation. A cohort of 178 patients transplanted during the same period with similar clinical characteristics were used for comparison of key outcomes. RESULTS. All livers were perfused in accordance to the COR protocol without incidences and transplanted successfully. Early allograft dysfunction was observed in 2 (11.1%) cases after COR. Liver elasticity measurements indicated normal healthy liver parenchyma at the last follow-up. Graft survival demonstrated excellent outcomes after COR. The 1-, 3-, and 5-year patient survival rates were 100%, 100%, and 93.8% compared with 84.5%, 82.0%, and 75.8% in the control group (P = 0.12). CONCLUSIONS. The present study demonstrates excellent clinical outcomes after COR before liver transplantation. Comparison with a control cohort shows superiority of graft survival. Further evidence is needed to assess this promising method to improve organ preservation, finally.
format Online
Article
Text
id pubmed-7145002
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-71450022020-04-17 Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation Hoyer, Dieter P. Benkö, Tamas Manka, Paul von Horn, Charlotte Treckmann, Juergen W. Paul, Andreas Minor, Thomas Transplant Direct Liver Transplantation Controlled oxygenated rewarming (COR) has been shown to be a feasible and safe method in clinical practice and to reduce peak serum transaminases after liver transplantation. This study aimed to demonstrate further clinical experience of this method of now 18 clinical liver transplantations utilizing COR and demonstrate the long-term results. METHODS. In this extended series of 18 patients, cold-stored livers were subjected to machine-assisted slow COR for ≈120 minutes before transplantation. A cohort of 178 patients transplanted during the same period with similar clinical characteristics were used for comparison of key outcomes. RESULTS. All livers were perfused in accordance to the COR protocol without incidences and transplanted successfully. Early allograft dysfunction was observed in 2 (11.1%) cases after COR. Liver elasticity measurements indicated normal healthy liver parenchyma at the last follow-up. Graft survival demonstrated excellent outcomes after COR. The 1-, 3-, and 5-year patient survival rates were 100%, 100%, and 93.8% compared with 84.5%, 82.0%, and 75.8% in the control group (P = 0.12). CONCLUSIONS. The present study demonstrates excellent clinical outcomes after COR before liver transplantation. Comparison with a control cohort shows superiority of graft survival. Further evidence is needed to assess this promising method to improve organ preservation, finally. Wolters Kluwer Health 2020-03-13 /pmc/articles/PMC7145002/ /pubmed/32309628 http://dx.doi.org/10.1097/TXD.0000000000000987 Text en Copyright © 2020 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Liver Transplantation
Hoyer, Dieter P.
Benkö, Tamas
Manka, Paul
von Horn, Charlotte
Treckmann, Juergen W.
Paul, Andreas
Minor, Thomas
Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
title Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
title_full Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
title_fullStr Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
title_full_unstemmed Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
title_short Long-term Outcomes After Controlled Oxygenated Rewarming of Human Livers Before Transplantation
title_sort long-term outcomes after controlled oxygenated rewarming of human livers before transplantation
topic Liver Transplantation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145002/
https://www.ncbi.nlm.nih.gov/pubmed/32309628
http://dx.doi.org/10.1097/TXD.0000000000000987
work_keys_str_mv AT hoyerdieterp longtermoutcomesaftercontrolledoxygenatedrewarmingofhumanliversbeforetransplantation
AT benkotamas longtermoutcomesaftercontrolledoxygenatedrewarmingofhumanliversbeforetransplantation
AT mankapaul longtermoutcomesaftercontrolledoxygenatedrewarmingofhumanliversbeforetransplantation
AT vonhorncharlotte longtermoutcomesaftercontrolledoxygenatedrewarmingofhumanliversbeforetransplantation
AT treckmannjuergenw longtermoutcomesaftercontrolledoxygenatedrewarmingofhumanliversbeforetransplantation
AT paulandreas longtermoutcomesaftercontrolledoxygenatedrewarmingofhumanliversbeforetransplantation
AT minorthomas longtermoutcomesaftercontrolledoxygenatedrewarmingofhumanliversbeforetransplantation