Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis

Portal vein thrombosis seems to be dependent on local hypercoagulation and venous stasis; data regarding endothelial damage are lacking. METHODS: von Willebrad factor, a marker of endothelial damage/perturbation, factor VIII, and lipopolysaccharides (LPS) were studied in the portal and systemic circ...

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Autores principales: Praktiknjo, Michael, Trebicka, Jonel, Carnevale, Roberto, Pastori, Daniele, Queck, Alexander, Ettorre, Evaristo, Violi, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145026/
https://www.ncbi.nlm.nih.gov/pubmed/32032127
http://dx.doi.org/10.14309/ctg.0000000000000123
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author Praktiknjo, Michael
Trebicka, Jonel
Carnevale, Roberto
Pastori, Daniele
Queck, Alexander
Ettorre, Evaristo
Violi, Francesco
author_facet Praktiknjo, Michael
Trebicka, Jonel
Carnevale, Roberto
Pastori, Daniele
Queck, Alexander
Ettorre, Evaristo
Violi, Francesco
author_sort Praktiknjo, Michael
collection PubMed
description Portal vein thrombosis seems to be dependent on local hypercoagulation and venous stasis; data regarding endothelial damage are lacking. METHODS: von Willebrad factor, a marker of endothelial damage/perturbation, factor VIII, and lipopolysaccharides (LPS) were studied in the portal and systemic circulation of 20 cirrhotic patients undergoing transjugular intrahepatic portosystemic procedure. RESULTS: von Willebrad factor, factor VIII, and LPS were higher in the portal compared with systemic circulation, with a significant correlation between LPS and the other 2 variables. DISCUSSION: Endothelial damage and hypercoagulation coexist in the portal tree of patients with cirrhosis, and both could contribute to portal vein thrombosis. LPS may be a potential trigger of endothelial damage.
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spelling pubmed-71450262020-04-17 Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis Praktiknjo, Michael Trebicka, Jonel Carnevale, Roberto Pastori, Daniele Queck, Alexander Ettorre, Evaristo Violi, Francesco Clin Transl Gastroenterol Article Portal vein thrombosis seems to be dependent on local hypercoagulation and venous stasis; data regarding endothelial damage are lacking. METHODS: von Willebrad factor, a marker of endothelial damage/perturbation, factor VIII, and lipopolysaccharides (LPS) were studied in the portal and systemic circulation of 20 cirrhotic patients undergoing transjugular intrahepatic portosystemic procedure. RESULTS: von Willebrad factor, factor VIII, and LPS were higher in the portal compared with systemic circulation, with a significant correlation between LPS and the other 2 variables. DISCUSSION: Endothelial damage and hypercoagulation coexist in the portal tree of patients with cirrhosis, and both could contribute to portal vein thrombosis. LPS may be a potential trigger of endothelial damage. Wolters Kluwer 2020-02-05 /pmc/articles/PMC7145026/ /pubmed/32032127 http://dx.doi.org/10.14309/ctg.0000000000000123 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work, provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Article
Praktiknjo, Michael
Trebicka, Jonel
Carnevale, Roberto
Pastori, Daniele
Queck, Alexander
Ettorre, Evaristo
Violi, Francesco
Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis
title Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis
title_full Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis
title_fullStr Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis
title_full_unstemmed Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis
title_short Von Willebrand and Factor VIII Portosystemic Circulation Gradient in Cirrhosis: Implications for Portal Vein Thrombosis
title_sort von willebrand and factor viii portosystemic circulation gradient in cirrhosis: implications for portal vein thrombosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145026/
https://www.ncbi.nlm.nih.gov/pubmed/32032127
http://dx.doi.org/10.14309/ctg.0000000000000123
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