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Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations

Serum pepsinogens have been widely acknowledged as gastric mucosal biomarkers; however, a multicountry report on the benefits of pepsinogens as biomarkers has not yet been published. We analyzed 1,206 sera and gastric mucosal samples collected from Bangladesh, Bhutan, Indonesia, Myanmar, Nepal and T...

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Autores principales: Miftahussurur, Muhammad, Waskito, Langgeng Agung, Aftab, Hafeza, Vilaichone, Ratha-korn, Subsomwong, Phawinee, Nusi, Iswan Abbas, Syam, Ari Fahrial, Ratanachu-ek, Thawee, Doohan, Dalla, Siregar, Gontar, Rezkitha, Yudith Annisa Ayu, Fauzia, Kartika Afrida, Mahachai, Varocha, Yamaoka, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145115/
https://www.ncbi.nlm.nih.gov/pubmed/32271765
http://dx.doi.org/10.1371/journal.pone.0230064
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author Miftahussurur, Muhammad
Waskito, Langgeng Agung
Aftab, Hafeza
Vilaichone, Ratha-korn
Subsomwong, Phawinee
Nusi, Iswan Abbas
Syam, Ari Fahrial
Ratanachu-ek, Thawee
Doohan, Dalla
Siregar, Gontar
Rezkitha, Yudith Annisa Ayu
Fauzia, Kartika Afrida
Mahachai, Varocha
Yamaoka, Yoshio
author_facet Miftahussurur, Muhammad
Waskito, Langgeng Agung
Aftab, Hafeza
Vilaichone, Ratha-korn
Subsomwong, Phawinee
Nusi, Iswan Abbas
Syam, Ari Fahrial
Ratanachu-ek, Thawee
Doohan, Dalla
Siregar, Gontar
Rezkitha, Yudith Annisa Ayu
Fauzia, Kartika Afrida
Mahachai, Varocha
Yamaoka, Yoshio
author_sort Miftahussurur, Muhammad
collection PubMed
description Serum pepsinogens have been widely acknowledged as gastric mucosal biomarkers; however, a multicountry report on the benefits of pepsinogens as biomarkers has not yet been published. We analyzed 1,206 sera and gastric mucosal samples collected from Bangladesh, Bhutan, Indonesia, Myanmar, Nepal and Thailand then assessed the association between gastric mucosal changes and Helicobacter pylori infection. The new cutoff values for serum pepsinogen values were evaluated using a receiver operating characteristic analysis. The participants with H. pylori infection had significantly lower pepsinogen I and higher pepsinogen II values, but a lower pepsinogen I/II ratio than participants without the infection (all P < .001). The pepsinogen I and pepsinogen I/II values were significantly higher and lower, respectively, in individuals with atrophic gastritis than in those without (both P < .001). Among uninfected individuals, only the pepsinogen I/II ratio was significantly lower in atrophic individuals. Pepsinogen I/II ratio also were significantly different between disease among H. pylori-positive and H. pylori-negative individuals, suggesting the pepsinogen I/II ratio is a robust biomarker for determining both chronic and atrophic gastritis. The cutoffs for detecting chronic and atrophic gastritis for the pepsinogen I/II ratio were 4.65 and 4.95, respectively. In conclusion, pepsinogen levels are useful biomarker for both chronic gastritis and atrophic gastritis, but they should be used with caution. Population-based validation is necessary to determine the best cutoff values. Among all pepsinogen values, the pepsinogen I/II ratio was the most reliable gastric mucosal-change biomarker.
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spelling pubmed-71451152020-04-14 Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations Miftahussurur, Muhammad Waskito, Langgeng Agung Aftab, Hafeza Vilaichone, Ratha-korn Subsomwong, Phawinee Nusi, Iswan Abbas Syam, Ari Fahrial Ratanachu-ek, Thawee Doohan, Dalla Siregar, Gontar Rezkitha, Yudith Annisa Ayu Fauzia, Kartika Afrida Mahachai, Varocha Yamaoka, Yoshio PLoS One Research Article Serum pepsinogens have been widely acknowledged as gastric mucosal biomarkers; however, a multicountry report on the benefits of pepsinogens as biomarkers has not yet been published. We analyzed 1,206 sera and gastric mucosal samples collected from Bangladesh, Bhutan, Indonesia, Myanmar, Nepal and Thailand then assessed the association between gastric mucosal changes and Helicobacter pylori infection. The new cutoff values for serum pepsinogen values were evaluated using a receiver operating characteristic analysis. The participants with H. pylori infection had significantly lower pepsinogen I and higher pepsinogen II values, but a lower pepsinogen I/II ratio than participants without the infection (all P < .001). The pepsinogen I and pepsinogen I/II values were significantly higher and lower, respectively, in individuals with atrophic gastritis than in those without (both P < .001). Among uninfected individuals, only the pepsinogen I/II ratio was significantly lower in atrophic individuals. Pepsinogen I/II ratio also were significantly different between disease among H. pylori-positive and H. pylori-negative individuals, suggesting the pepsinogen I/II ratio is a robust biomarker for determining both chronic and atrophic gastritis. The cutoffs for detecting chronic and atrophic gastritis for the pepsinogen I/II ratio were 4.65 and 4.95, respectively. In conclusion, pepsinogen levels are useful biomarker for both chronic gastritis and atrophic gastritis, but they should be used with caution. Population-based validation is necessary to determine the best cutoff values. Among all pepsinogen values, the pepsinogen I/II ratio was the most reliable gastric mucosal-change biomarker. Public Library of Science 2020-04-09 /pmc/articles/PMC7145115/ /pubmed/32271765 http://dx.doi.org/10.1371/journal.pone.0230064 Text en © 2020 Miftahussurur et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Miftahussurur, Muhammad
Waskito, Langgeng Agung
Aftab, Hafeza
Vilaichone, Ratha-korn
Subsomwong, Phawinee
Nusi, Iswan Abbas
Syam, Ari Fahrial
Ratanachu-ek, Thawee
Doohan, Dalla
Siregar, Gontar
Rezkitha, Yudith Annisa Ayu
Fauzia, Kartika Afrida
Mahachai, Varocha
Yamaoka, Yoshio
Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations
title Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations
title_full Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations
title_fullStr Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations
title_full_unstemmed Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations
title_short Serum pepsinogens as a gastric cancer and gastritis biomarker in South and Southeast Asian populations
title_sort serum pepsinogens as a gastric cancer and gastritis biomarker in south and southeast asian populations
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145115/
https://www.ncbi.nlm.nih.gov/pubmed/32271765
http://dx.doi.org/10.1371/journal.pone.0230064
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