Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids

Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We pre...

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Detalles Bibliográficos
Autores principales: Sundaram, Suneha, Vuppalanchi, Raj, Saxena, Romil, Chalasani, Naga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145177/
https://www.ncbi.nlm.nih.gov/pubmed/32309510
http://dx.doi.org/10.14309/crj.0000000000000319
Descripción
Sumario:Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.

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