Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids

Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We pre...

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Autores principales: Sundaram, Suneha, Vuppalanchi, Raj, Saxena, Romil, Chalasani, Naga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145177/
https://www.ncbi.nlm.nih.gov/pubmed/32309510
http://dx.doi.org/10.14309/crj.0000000000000319
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author Sundaram, Suneha
Vuppalanchi, Raj
Saxena, Romil
Chalasani, Naga
author_facet Sundaram, Suneha
Vuppalanchi, Raj
Saxena, Romil
Chalasani, Naga
author_sort Sundaram, Suneha
collection PubMed
description Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI.
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spelling pubmed-71451772020-04-17 Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids Sundaram, Suneha Vuppalanchi, Raj Saxena, Romil Chalasani, Naga ACG Case Rep J Case Report Idiosyncratic drug-induced liver injury (DILI), when severe, can be associated with significant morbidity and mortality. Currently, there are no specific therapies for DILI, apart from corticosteroids for drug-induced autoimmune hepatitis caused by drugs such as nitrofurantoin or minocycline. We present 2 cases of DILI that improved with corticosteroid therapy despite the lack of autoimmune features by serology or histology. The current observations make a strong case for formally testing corticosteroids in a controlled trial in patients with suspected DILI. Wolters Kluwer 2020-02-24 /pmc/articles/PMC7145177/ /pubmed/32309510 http://dx.doi.org/10.14309/crj.0000000000000319 Text en © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Sundaram, Suneha
Vuppalanchi, Raj
Saxena, Romil
Chalasani, Naga
Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
title Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
title_full Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
title_fullStr Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
title_full_unstemmed Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
title_short Treatment of Idiosyncratic Drug-Induced Liver Injury Using Steroids
title_sort treatment of idiosyncratic drug-induced liver injury using steroids
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145177/
https://www.ncbi.nlm.nih.gov/pubmed/32309510
http://dx.doi.org/10.14309/crj.0000000000000319
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