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A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope

Compact CRISPR/Cas9 systems that can be packaged into an adeno-associated virus (AAV) hold great promise for gene therapy. Unfortunately, currently available small Cas9 nucleases either display low activity or require a long protospacer adjacent motif (PAM) sequence, limiting their extensive applica...

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Detalles Bibliográficos
Autores principales:	Hu, Ziying, Wang, Shuai, Zhang, Chengdong, Gao, Ning, Li, Miaomiao, Wang, Deqian, Wang, Daqi, Liu, Dong, Liu, Huihui, Ong, Sang-Ging, Wang, Hongyan, Wang, Yongming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Methods and Resources
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145270/ https://www.ncbi.nlm.nih.gov/pubmed/32226015 http://dx.doi.org/10.1371/journal.pbio.3000686

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