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New Peptide-Based Pharmacophore Activates 20S Proteasome

The proteasome is a pivotal element of controlled proteolysis, responsible for the catabolic arm of proteostasis. By inducing apoptosis, small molecule inhibitors of proteasome peptidolytic activities are successfully utilized in treatment of blood cancers. However, the clinical potential of proteas...

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Detalles Bibliográficos
Autores principales:	Osmulski, Paweł A., Karpowicz, Przemysław, Jankowska, Elżbieta, Bohmann, Jonathan, Pickering, Andrew M., Gaczyńska, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145288/ https://www.ncbi.nlm.nih.gov/pubmed/32235805 http://dx.doi.org/10.3390/molecules25061439

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