Cargando…
Rapid regulation of vesicle priming explains synaptic facilitation despite heterogeneous vesicle:Ca(2+) channel distances
Chemical synaptic transmission relies on the Ca(2+)-induced fusion of transmitter-laden vesicles whose coupling distance to Ca(2+) channels determines synaptic release probability and short-term plasticity, the facilitation or depression of repetitive responses. Here, using electron- and super-resol...
Autores principales: | Kobbersmed, Janus RL, Grasskamp, Andreas T, Jusyte, Meida, Böhme, Mathias A, Ditlevsen, Susanne, Sørensen, Jakob Balslev, Walter, Alexander M |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145420/ https://www.ncbi.nlm.nih.gov/pubmed/32077852 http://dx.doi.org/10.7554/eLife.51032 |
Ejemplares similares
-
Spontaneous neurotransmission at evocable synapses predicts their responsiveness to action potentials
por: Grasskamp, Andreas T., et al.
Publicado: (2023) -
Allosteric stabilization of calcium and phosphoinositide dual binding engages several synaptotagmins in fast exocytosis
por: Kobbersmed, Janus RL, et al.
Publicado: (2022) -
Synaptic vesicles are “primed” for fast clathrin-mediated endocytosis at the ribbon synapse
por: Pelassa, Ilaria, et al.
Publicado: (2014) -
Tomosyn Inhibits Synaptic Vesicle Priming in
Caenorhabditis elegans
por: Gracheva, Elena O, et al.
Publicado: (2006) -
Additive effects on the energy barrier for synaptic vesicle fusion cause
supralinear effects on the vesicle fusion rate
por: Schotten, Sebastiaan, et al.
Publicado: (2015)