PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation

The inability of cells to adapt to increased environmental tonicity can lead to inflammatory gene expression and pathogenesis. The Rel family of transcription factors TonEBP and NF-κB p65 play critical roles in the switch from osmoadaptive homeostasis to inflammation, respectively. Here we identifie...

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Detalles Bibliográficos
Autores principales: Farabaugh, Kenneth T, Krokowski, Dawid, Guan, Bo-Jhih, Gao, Zhaofeng, Gao, Xing-Huang, Wu, Jing, Jobava, Raul, Ray, Greeshma, de Jesus, Tristan J, Bianchi, Massimiliano G, Chukwurah, Evelyn, Bussolati, Ovidio, Kilberg, Michael, Buchner, David A, Sen, Ganes C, Cotton, Calvin, McDonald, Christine, Longworth, Michelle, Ramakrishnan, Parameswaran, Hatzoglou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145421/
https://www.ncbi.nlm.nih.gov/pubmed/32175843
http://dx.doi.org/10.7554/eLife.52241

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