Identification of a novel structure-specific endonuclease AziN that contributes to the repair of azinomycin B-mediated DNA interstrand crosslinks

DNA interstrand crosslinks (ICLs) induced by the highly genotoxic agent azinomycin B (AZB) can cause severe perturbation of DNA structure and even cell death. However, Streptomyces sahachiroi, the strain that produces AZB, seems almost impervious to this danger because of its diverse and distinctive...

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Detalles Bibliográficos
Autores principales: Chen, Xiaorong, Sun, Yuedi, Wang, Shan, Ying, Kun, Xiao, Le, Liu, Kai, Zuo, Xiuli, He, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145581/
https://www.ncbi.nlm.nih.gov/pubmed/31713613
http://dx.doi.org/10.1093/nar/gkz1067

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145581/
https://www.ncbi.nlm.nih.gov/pubmed/31713613
http://dx.doi.org/10.1093/nar/gkz1067

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