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Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations

The RNA guanine-N7 methyltransferase (RNMT) in complex with RNMT-activating miniprotein (RAM) catalyses the formation of a N7-methylated guanosine cap structure on the 5′ end of nascent RNA polymerase II transcripts. The mRNA cap protects the primary transcript from exonucleases and recruits cap-bin...

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Detalles Bibliográficos
Autores principales:	Bueren-Calabuig, Juan A, G. Bage, Marcus, Cowling, Victoria H, Pisliakov, Andrei V
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145595/ https://www.ncbi.nlm.nih.gov/pubmed/31329932 http://dx.doi.org/10.1093/nar/gkz613

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