‘Drc’, a structurally novel ssDNA-binding transcription regulator of N4-related bacterial viruses

Bacterial viruses encode a vast number of ORFan genes that lack similarity to any other known proteins. Here, we present a 2.20 Å crystal structure of N4-related Pseudomonas virus LUZ7 ORFan gp14, and elucidate its function. We demonstrate that gp14, termed here as Drc (ssDNA-binding RNA Polymerase...

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Detalles Bibliográficos
Autores principales: Boon, Maarten, De Zitter, Elke, De Smet, Jeroen, Wagemans, Jeroen, Voet, Marleen, Pennemann, Friederike L, Schalck, Thomas, Kuznedelov, Konstantin, Severinov, Konstantin, Van Meervelt, Luc, De Maeyer, Marc, Lavigne, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145618/
https://www.ncbi.nlm.nih.gov/pubmed/31724707
http://dx.doi.org/10.1093/nar/gkz1048

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