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Targeted DNA methylation of neurodegenerative disease genes via homology directed repair

DNA methyltransferases (DNMTs) are thought to be involved in the cellular response to DNA damage, thus linking DNA repair mechanisms with DNA methylation. In this study we present Homology Assisted Repair Dependent Epigenetic eNgineering (HARDEN), a novel method of targeted DNA methylation that util...

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Detalles Bibliográficos
Autores principales:	Cali, Christopher P, Park, Daniel S, Lee, Edward B
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145628/ https://www.ncbi.nlm.nih.gov/pubmed/31680172 http://dx.doi.org/10.1093/nar/gkz979

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