A DNA aptamer for binding and inhibition of DNA methyltransferase 1

DNA methyltransferases (DNMTs) are enzymes responsible for establishing and maintaining DNA methylation in cells. DNMT inhibition is actively pursued in cancer treatment, dominantly through the formation of irreversible covalent complexes between small molecular compounds and DNMTs that suffers from...

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Detalles Bibliográficos
Autores principales: Wang, Linlin, Lee, Ju Yong, Gao, Linfeng, Yin, Jiekai, Duan, Yaokai, Jimenez, Luis A, Adkins, Gary Brent, Ren, Wendan, Li, Linhui, Fang, Jian, Wang, Yinsheng, Song, Jikui, Zhong, Wenwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145629/
https://www.ncbi.nlm.nih.gov/pubmed/31733056
http://dx.doi.org/10.1093/nar/gkz1083

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