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RETRACTED: CGVD: a genomic variation database for Chinese populations
Precision medicine calls upon deeper coverage of population-based sequencing and thorough gene-content and phenotype-based analysis, which lead to a population-associated genomic variation map or database. The Chinese Genomic Variation Database (CGVD; https://bigd.big.ac.cn/cgvd/) is such a database...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145633/ https://www.ncbi.nlm.nih.gov/pubmed/31665422 http://dx.doi.org/10.1093/nar/gkz952 |
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author | Zeng, Jingyao Yuan, Na Zhu, Junwei Pan, Mengyu Zhang, Hao Wang, Qi Shi, Shuo Du, Zhenglin Xiao, Jingfa |
author_facet | Zeng, Jingyao Yuan, Na Zhu, Junwei Pan, Mengyu Zhang, Hao Wang, Qi Shi, Shuo Du, Zhenglin Xiao, Jingfa |
author_sort | Zeng, Jingyao |
collection | PubMed |
description | Precision medicine calls upon deeper coverage of population-based sequencing and thorough gene-content and phenotype-based analysis, which lead to a population-associated genomic variation map or database. The Chinese Genomic Variation Database (CGVD; https://bigd.big.ac.cn/cgvd/) is such a database that has combined 48.30 million (M) SNVs and 5.77 M small indels, identified from 991 Chinese individuals of the Chinese Academy of Sciences Precision Medicine Initiative Project (CASPMI) and 301 Chinese individuals of the 1000 Genomes Project (1KGP). The CASPMI project includes whole-genome sequencing data (WGS, 25–30×) from ∼1000 healthy individuals of the CASPMI cohort. To facilitate the usage of such variations for pharmacogenomics studies, star-allele frequencies of the drug-related genes in the CASPMI and 1KGP populations are calculated and provided in CGVD. As one of the important database resources in BIG Data Center, CGVD will continue to collect more genomic variations and to curate structural and functional annotations to support population-based healthcare projects and studies in China and worldwide. |
format | Online Article Text |
id | pubmed-7145633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-71456332020-04-13 RETRACTED: CGVD: a genomic variation database for Chinese populations Zeng, Jingyao Yuan, Na Zhu, Junwei Pan, Mengyu Zhang, Hao Wang, Qi Shi, Shuo Du, Zhenglin Xiao, Jingfa Nucleic Acids Res Database Issue Precision medicine calls upon deeper coverage of population-based sequencing and thorough gene-content and phenotype-based analysis, which lead to a population-associated genomic variation map or database. The Chinese Genomic Variation Database (CGVD; https://bigd.big.ac.cn/cgvd/) is such a database that has combined 48.30 million (M) SNVs and 5.77 M small indels, identified from 991 Chinese individuals of the Chinese Academy of Sciences Precision Medicine Initiative Project (CASPMI) and 301 Chinese individuals of the 1000 Genomes Project (1KGP). The CASPMI project includes whole-genome sequencing data (WGS, 25–30×) from ∼1000 healthy individuals of the CASPMI cohort. To facilitate the usage of such variations for pharmacogenomics studies, star-allele frequencies of the drug-related genes in the CASPMI and 1KGP populations are calculated and provided in CGVD. As one of the important database resources in BIG Data Center, CGVD will continue to collect more genomic variations and to curate structural and functional annotations to support population-based healthcare projects and studies in China and worldwide. Oxford University Press 2020-01-08 2019-10-30 /pmc/articles/PMC7145633/ /pubmed/31665422 http://dx.doi.org/10.1093/nar/gkz952 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Database Issue Zeng, Jingyao Yuan, Na Zhu, Junwei Pan, Mengyu Zhang, Hao Wang, Qi Shi, Shuo Du, Zhenglin Xiao, Jingfa RETRACTED: CGVD: a genomic variation database for Chinese populations |
title | RETRACTED: CGVD: a genomic variation database for Chinese populations |
title_full | RETRACTED: CGVD: a genomic variation database for Chinese populations |
title_fullStr | RETRACTED: CGVD: a genomic variation database for Chinese populations |
title_full_unstemmed | RETRACTED: CGVD: a genomic variation database for Chinese populations |
title_short | RETRACTED: CGVD: a genomic variation database for Chinese populations |
title_sort | retracted: cgvd: a genomic variation database for chinese populations |
topic | Database Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145633/ https://www.ncbi.nlm.nih.gov/pubmed/31665422 http://dx.doi.org/10.1093/nar/gkz952 |
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