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USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells

Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are predominantly repaired by non-homologous end joining (NHEJ). IR-induced DNA damage activates autophagy, an intracellular degradation process that delivers cytoplasmic components to the lysosome. We identified the deubiquitinase USP1...

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Detalles Bibliográficos
Autores principales:	Sharma, Arishya, Alswillah, Turkeya, Kapoor, Isha, Debjani, Pal, Willard, Belinda, Summers, Matthew K, Gong, Zihua, Almasan, Alexandru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145659/ https://www.ncbi.nlm.nih.gov/pubmed/31740976 http://dx.doi.org/10.1093/nar/gkz1103

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