Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation

Alternative splicing is emerging as an oncogenic mechanism. In prostate cancer, generation of constitutively active forms of androgen receptor (AR) variants including AR-V7 plays an important role in progression of castration-resistant prostate cancer (CRPC). AR-V7 is generated by alternative splici...

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Detalles Bibliográficos
Autores principales: Duan, Lingling, Chen, Zhenhua, Lu, Jun, Liang, Yanping, Wang, Ming, Roggero, Carlos M, Zhang, Qing-Jun, Gao, Jason, Fang, Yong, Cao, Jiazheng, Lu, Jian, Zhao, Hongwei, Dang, Andrew, Pong, Rey-Chen, Hernandez, Elizabeth, Chang, Chun-Mien, Hoang, David T, Ahn, Jung-Mo, Xiao, Guanghua, Wang, Rui-tao, Yu, Kai-jiang, Kapur, Payal, Rizo, Josep, Hsieh, Jer-Tsong, Luo, Junhang, Liu, Zhi-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145715/
https://www.ncbi.nlm.nih.gov/pubmed/31647098
http://dx.doi.org/10.1093/nar/gkz1004

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