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Targeted nanopore sequencing with Cas9-guided adaptor ligation
Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection. Current methods(1-4) are limited by the loss of native modifications, short read length, high input requirements, low yield, or long protocols. H...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145730/ https://www.ncbi.nlm.nih.gov/pubmed/32042167 http://dx.doi.org/10.1038/s41587-020-0407-5 |