Cargando…

Metabolic alterations in immune cells associate with progression to type 1 diabetes

AIMS/HYPOTHESIS: Previous metabolomics studies suggest that type 1 diabetes is preceded by specific metabolic disturbances. The aim of this study was to investigate whether distinct metabolic patterns occur in peripheral blood mononuclear cells (PBMCs) of children who later develop pancreatic beta c...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sen, Partho, Dickens, Alex M., López-Bascón, María Asunción, Lindeman, Tuomas, Kemppainen, Esko, Lamichhane, Santosh, Rönkkö, Tuukka, Ilonen, Jorma, Toppari, Jorma, Veijola, Riitta, Hyöty, Heikki, Hyötyläinen, Tuulia, Knip, Mikael, Orešič, Matej
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145788/ https://www.ncbi.nlm.nih.gov/pubmed/32043185 http://dx.doi.org/10.1007/s00125-020-05107-6

Ejemplares similares

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes
por: Lamichhane, Santosh, et al.
Publicado: (2019)

Dynamics of Plasma Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes – Type 1 Diabetes Prediction and Prevention Study (DIPP)
por: Lamichhane, Santosh, et al.
Publicado: (2018)

Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children
por: Lamichhane, Santosh, et al.
Publicado: (2023)

A longitudinal plasma lipidomics dataset from children who developed islet autoimmunity and type 1 diabetes
por: Lamichhane, Santosh, et al.
Publicado: (2018)

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease
por: Sen, Partho, et al.
Publicado: (2019)

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes
por: Lamichhane, Santosh, et al.
Publicado: (2019)

Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis
por: Dickens, Alex M., et al.
Publicado: (2020)

Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life
por: Lamichhane, Santosh, et al.
Publicado: (2022)

Cord Serum Lipidome in Prediction of Islet Autoimmunity and Type 1 Diabetes
por: Orešič, Matej, et al.
Publicado: (2013)

CXADR polymorphism rs6517774 modifies islet autoimmunity characteristics and exhibits sex disparity
por: Nygård, Lucas, et al.
Publicado: (2023)

An Increase in Serum 25-Hydroxyvitamin D Concentrations Preceded a Plateau in Type 1 Diabetes Incidence in Finnish Children
por: Mäkinen, Marjaana, et al.
Publicado: (2014)

Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
por: Hirvonen, M. Karoliina, et al.
Publicado: (2023)

Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
por: Oikarinen, Maarit, et al.
Publicado: (2021)

The methylome of the gut microbiome: disparate Dam methylation patterns in intestinal Bacteroides dorei
por: Leonard, Michael T., et al.
Publicado: (2014)

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes
por: Lietzen, Niina, et al.
Publicado: (2017)

Autoantibodies to N-terminally Truncated GAD(65)(96-585): HLA Associations and Predictive Value for Type 1 Diabetes
por: Pöllänen, Petra M, et al.
Publicado: (2021)

Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects
por: Laine, Antti-Pekka, et al.
Publicado: (2022)

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes
por: Oikarinen, Sami, et al.
Publicado: (2011)

Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes
por: Lamichhane, Santosh, et al.
Publicado: (2022)

Maternal Enterovirus Infection as a Risk Factor for Type 1 Diabetes in the Exposed Offspring
por: Viskari, Hanna, et al.
Publicado: (2012)

Diagnostic Methods for and Clinical Pictures of Polyomavirus Primary Infections in Children, Finland
por: Chen, Tingting, et al.
Publicado: (2014)

Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes
por: Nurminen, Noora, et al.
Publicado: (2021)

Dynamics of Islet Autoantibodies During Prospective Follow-Up From Birth to Age 15 Years
por: Pöllänen, Petra M, et al.
Publicado: (2020)

Serum 25-Hydroxyvitamin D Concentrations at Birth in Children Screened for HLA-DQB1 Conferred Risk for Type 1 Diabetes
por: Mäkinen, Marjaana, et al.
Publicado: (2019)

Age-associated DNA methylation changes in immune genes, histone modifiers and chromatin remodeling factors within 5 years after birth in human blood leukocytes
por: Acevedo, Nathalie, et al.
Publicado: (2015)

B-Cell Responses to Human Bocaviruses 1–4: New Insights from a Childhood Follow-Up Study
por: Kantola, Kalle, et al.
Publicado: (2015)

Correction: B-Cell Responses to Human Bocaviruses 1–4: New Insights from a Childhood Follow-Up Study
por: Kantola, Kalle, et al.
Publicado: (2017)

Impact of Intranasal Insulin on Insulin Antibody Affinity and Isotypes in Young Children With HLA-Conferred Susceptibility to Type 1 Diabetes
por: Ryhänen, Samppa J., et al.
Publicado: (2011)

Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA
por: Suomi, Tomi, et al.
Publicado: (2022)

Age at Development of Type 1 Diabetes– and Celiac Disease–Associated Antibodies and Clinical Disease in Genetically Susceptible Children Observed From Birth
por: Simell, Satu, et al.
Publicado: (2010)

The Gut Microbiota Modulates Glycaemic Control and Serum Metabolite Profiles in Non-Obese Diabetic Mice
por: Greiner, Thomas U., et al.
Publicado: (2014)

Effect of the PTPN22 and INS Risk Genotypes on the Progression to Clinical Type 1 Diabetes After the Initiation of β-Cell Autoimmunity
por: Lempainen, Johanna, et al.
Publicado: (2012)

Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations
por: Lamichhane, Santosh, et al.
Publicado: (2021)

Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells
por: Sen, Partho, et al.
Publicado: (2018)

FOXP3+ Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children
por: Viisanen, Tyyne, et al.
Publicado: (2019)

Circulating CXCR5(−)PD-1(hi) peripheral T helper cells are associated with progression to type 1 diabetes
por: Ekman, Ilse, et al.
Publicado: (2019)

Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes
por: Gazali, Ahmad M., et al.
Publicado: (2020)

What is the role of puberty in the development of islet autoimmunity and progression to type 1 diabetes?
por: Peltonen, Essi J., et al.
Publicado: (2023)

A Joint Modeling Approach for Childhood Meat, Fish and Egg Consumption and the Risk of Advanced Islet Autoimmunity
por: Syrjälä, Essi, et al.
Publicado: (2019)

Maternal Vitamin C and Iron Intake during Pregnancy and the Risk of Islet Autoimmunity and Type 1 Diabetes in Children: A Birth Cohort Study
por: Mattila, Markus, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_uulqaptctumqntl1t81rpl0c95