Cargando…

Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability

AIMS/HYPOTHESIS: High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was rediscovered to be a ‘danger signal’ (alarmin) that alerts the immune system once released extracellularly. Therefore, it has been recognised contributing to the pathogenesis of autoimmune diabet...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jing, Chen, Longmin, Wang, Faxi, Zou, Yuan, Li, Jingyi, Luo, Jiahui, Khan, Faheem, Sun, Fei, Li, Yang, Liu, Jing, Chen, Zhishui, Zhang, Shu, Xiong, Fei, Yu, Qilin, Li, Jinxiu, Huang, Kun, Adam, Bao-Ling, Zhou, Zhiguang, Eizirik, Decio L., Yang, Ping, Wang, Cong-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145789/ https://www.ncbi.nlm.nih.gov/pubmed/32072192 http://dx.doi.org/10.1007/s00125-020-05105-8

Ejemplares similares

Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization
por: Wang, Faxi, et al.
Publicado: (2019)

Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus
por: Chen, Longmin, et al.
Publicado: (2021)

The AHR Signaling Attenuates Autoimmune Responses During the Development of Type 1 Diabetes
por: Yue, Tiantian, et al.
Publicado: (2020)

Myo9b mutations are associated with altered dendritic cell functions and increased susceptibility to autoimmune diabetes onset
por: Zhang, Jing, et al.
Publicado: (2023)

Targeted Inhibition of FTO Demethylase Protects Mice Against LPS-Induced Septic Shock by Suppressing NLRP3 Inflammasome
por: Luo, Jiahui, et al.
Publicado: (2021)

Erratum. Loss of Mbd2 Protects Mice Against High-Fat Diet–Induced Obesity and Insulin Resistance by Regulating the Homeostasis of Energy Storage and Expenditure. Diabetes 2016;65:3384–3395
por: Cheng, Jia, et al.
Publicado: (2017)

HMGB1, anti-HMGB1 antibodies, and ratio of HMGB1/anti-HMGB1 antibodies as diagnosis indicator in fever of unknown origin
por: Chen, Mingkun, et al.
Publicado: (2021)

Release of HMGB1 in Podocytes Exacerbates Lipopolysaccharide-Induced Acute Kidney Injury
por: Gao, Zhao, et al.
Publicado: (2021)

MBD2 acts as a repressor to maintain the homeostasis of the Th1 program in type 1 diabetes by regulating the STAT1-IFN-γ axis
por: Yue, Tiantian, et al.
Publicado: (2021)

The performance of the alarmin HMGB1 in pediatric diseases: From lab to clinic
por: Li, Bo, et al.
Publicado: (2020)

Aging and stress induced β cell senescence and its implication in diabetes development
por: Li, Na, et al.
Publicado: (2019)

The Association of HMGB1 Gene with the Prognosis of HCC
por: Xiao, Jianbiao, et al.
Publicado: (2014)

HMGB1 Release Induced by EV71 Infection Exacerbates Blood-Brain Barrier Disruption via VE-cadherin Phosphorylation
por: You, Qiao, et al.
Publicado: (2023)

Sesamin attenuates intestinal injury in sepsis via the HMGB1/TLR4/IL-33 signalling pathway
por: Li, Zhi-Ling, et al.
Publicado: (2020)

The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review
por: Wang, Xuanbin, et al.
Publicado: (2015)

Inhibition of HMGB1 Overcomes Resistance to Radiation and Chemotherapy in Nasopharyngeal Carcinoma
por: Zhu, Xuewei, et al.
Publicado: (2020)

ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
por: Brozzi, Flora, et al.
Publicado: (2016)

HMGB1 knockdown increases MM cell vulnerability by regulating autophagy and DNA damage repair
por: Guo, Xing, et al.
Publicado: (2018)

Glycyrrhizin Protects Mice Against Experimental Autoimmune Encephalomyelitis by Inhibiting High-Mobility Group Box 1 (HMGB1) Expression and Neuronal HMGB1 Release
por: Sun, Yan, et al.
Publicado: (2018)

Neutrophil extracellular trap induced by HMGB1 exacerbates damages in the ischemic brain
por: Kim, Seung-Woo, et al.
Publicado: (2019)

On the Immense Variety and Complexity of Circumstances Conditioning Pancreatic β-Cell Apoptosis in Type 1 Diabetes
por: Eizirik, Decio L., et al.
Publicado: (2012)

HMGB1 in depression: An overview of microglial HMBG1 in the pathogenesis of depression
por: Huang, Xiao, et al.
Publicado: (2023)

Circulating HMGB1 and RAGE as Clinical Biomarkers in Malignant and Autoimmune Diseases
por: Pilzweger, Christin, et al.
Publicado: (2015)

Research on the Mechanism of HMGB1 Regulating Autoimmune Encephalomyelitis by Regulating NF-κB
por: Liu, Lijuan, et al.
Publicado: (2022)

Increased Serum High Mobility Group Box 1 (HMGB1) Concentration and the Altered Expression of HMGB1 and Its Receptor Advanced Glycation Endproducts in Pemphigus
por: Li, Jia-Yi, et al.
Publicado: (2017)

Pathogenic role of HMGB1 in SARS?
por: Chen, Guoqian, et al.
Publicado: (2004)

Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation
por: Yang, Huan, et al.
Publicado: (2019)

Cyclosporine-a attenuates retinal inflammation by inhibiting HMGB-1 formation in rats with type 2 diabetes mellitus
por: Wang, Peng, et al.
Publicado: (2020)

Molecular Footprints of the Immune Assault on Pancreatic Beta Cells in Type 1 Diabetes
por: Colli, Maikel L., et al.
Publicado: (2020)

HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases
por: Ren, Wenxuan, et al.
Publicado: (2023)

Targeting HMGB1: A Potential Therapeutic Strategy for Chronic Kidney Disease
por: Liu, Tongtong, et al.
Publicado: (2023)

Downregulation of HMGB1 in thymoma cells affects T cell differentiation
por: Li, Jian, et al.
Publicado: (2023)

Glycyrrhizin mitigates radiation‐induced acute lung injury by inhibiting the HMGB1/TLR4 signalling pathway
por: Zheng, Lei, et al.
Publicado: (2019)

SAT068 The Golgi Transmembrane Protein GOLM1 Maintains PD-L1 Protein Levels In Islet Beta Cells In Response To Type 1 Diabetic Inflammation
por: huang, fei, et al.
Publicado: (2023)

Ubc9 regulates the expression of MHC II in dendritic cells to enhance DSS-induced colitis by mediating RBPJ SUMOylation
por: Zhang, Jing, et al.
Publicado: (2023)

HMGB1 in inflammation and cancer
por: Wang, Shumin, et al.
Publicado: (2020)

Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis
por: Yang, Kun, et al.
Publicado: (2021)

Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling
por: Guo, Qingling, et al.
Publicado: (2021)

High-Mobility Group Box 1 (HMGB1) and Autophagy in Acute Lung Injury (ALI): A Review
por: Qu, Lihua, et al.
Publicado: (2019)

HMGB1 and Caveolin-1 related to RPE cell senescence in age-related macular degeneration
por: Sun, Shuo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_gtt42fahippmkojlvibcnhpaua