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Extracellular HMGB1 exacerbates autoimmune progression and recurrence of type 1 diabetes by impairing regulatory T cell stability

AIMS/HYPOTHESIS: High-mobility group box 1 (HMGB1), an evolutionarily conserved chromosomal protein, was rediscovered to be a ‘danger signal’ (alarmin) that alerts the immune system once released extracellularly. Therefore, it has been recognised contributing to the pathogenesis of autoimmune diabet...

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Detalles Bibliográficos
Autores principales:	Zhang, Jing, Chen, Longmin, Wang, Faxi, Zou, Yuan, Li, Jingyi, Luo, Jiahui, Khan, Faheem, Sun, Fei, Li, Yang, Liu, Jing, Chen, Zhishui, Zhang, Shu, Xiong, Fei, Yu, Qilin, Li, Jinxiu, Huang, Kun, Adam, Bao-Ling, Zhou, Zhiguang, Eizirik, Decio L., Yang, Ping, Wang, Cong-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145789/ https://www.ncbi.nlm.nih.gov/pubmed/32072192 http://dx.doi.org/10.1007/s00125-020-05105-8

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