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Caveolin-1 regulates the ASMase/ceramide-mediated radiation response of endothelial cells in the context of tumor–stroma interactions

The integral membrane protein caveolin-1 (CAV1) plays a central role in radioresistance-mediating tumor–stroma interactions of advanced prostate cancer (PCa). Among the tumor–stroma, endothelial cells (EC) evolved as critical determinants of the radiation response. CAV1 deficiency in angiogenic EC w...

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Detalles Bibliográficos
Autores principales: Ketteler, Julia, Wittka, Alina, Leonetti, Daniela, Roy, Victoria Veas, Estephan, Hala, Maier, Patrick, Reis, Henning, Herskind, Carsten, Jendrossek, Verena, Paris, Francois, Klein, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145831/
https://www.ncbi.nlm.nih.gov/pubmed/32273493
http://dx.doi.org/10.1038/s41419-020-2418-z