p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both the regulation and biological functions of asparagine in tumour cells remain largely unknown. Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulat...

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Detalles Bibliográficos
Autores principales: Deng, Longfei, Yao, Pengbo, Li, Le, Ji, Fansen, Zhao, Shuang, Xu, Chang, Lan, Xun, Jiang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145870/
https://www.ncbi.nlm.nih.gov/pubmed/32273511
http://dx.doi.org/10.1038/s41467-020-15573-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145870/
https://www.ncbi.nlm.nih.gov/pubmed/32273511
http://dx.doi.org/10.1038/s41467-020-15573-6

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