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p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both the regulation and biological functions of asparagine in tumour cells remain largely unknown. Here, we report that p53 suppresses asparagine synthesis through the transcriptional downregulat...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145870/ https://www.ncbi.nlm.nih.gov/pubmed/32273511 http://dx.doi.org/10.1038/s41467-020-15573-6 |