Cargando…

Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition

Background: Kidney function in preterm newborns may be impaired by many factors. Methods: 71 newborns with gestational age (GA) < 32 weeks were enrolled. Serum creatinine (sCr), cystatin C (CysC), beta-trace protein (BTP) and urea were measured at T0 (3rd day of life) and T36 (GA 36 weeks), and e...

Descripción completa

Detalles Bibliográficos
Autores principales: Monzani, Alice, Crespi, Ilaria, Genoni, Giulia, Edefonti, Alberto, Montini, Giovanni, Bellomo, Giorgio, Ferrero, Federica, Bellone, Simonetta, Prodam, Flavia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146188/
https://www.ncbi.nlm.nih.gov/pubmed/32121201
http://dx.doi.org/10.3390/nu12030651
_version_ 1783520143018557440
author Monzani, Alice
Crespi, Ilaria
Genoni, Giulia
Edefonti, Alberto
Montini, Giovanni
Bellomo, Giorgio
Ferrero, Federica
Bellone, Simonetta
Prodam, Flavia
author_facet Monzani, Alice
Crespi, Ilaria
Genoni, Giulia
Edefonti, Alberto
Montini, Giovanni
Bellomo, Giorgio
Ferrero, Federica
Bellone, Simonetta
Prodam, Flavia
author_sort Monzani, Alice
collection PubMed
description Background: Kidney function in preterm newborns may be impaired by many factors. Methods: 71 newborns with gestational age (GA) < 32 weeks were enrolled. Serum creatinine (sCr), cystatin C (CysC), beta-trace protein (BTP) and urea were measured at T0 (3rd day of life) and T36 (GA 36 weeks), and estimated glomerular filtration rate (eGFR) was calculated according to different formulas at T36. Pre-natal and post-natal kidney injury risk scores were calculated. Results: Newborns with GA ≤ 28 weeks had higher sCr at T0, and lower sCr, BTP and higher urea levels at T36 (p = 0.007, p = 0.005 and p = 0.029, respectively). eGFR values were not different according to GA when calculated by the formulas using only CysC, but were higher in subjects with GA ≤ 28 weeks according to the other formulas. The post-natal score was positively correlated with eGFR according to sCr-based formulas, but the correlations did not persist when adjusted for urea levels and GA. Conclusions: CysC-based eGFR values are not influenced by GA. Post-natal score shows a direct correlation with eGFR according to sCr-based formulas, not persisting after adjustment for GA and urea levels, implying the importance of the nutritional status, since more premature subjects receive a more aggressive nutritional regimen, testified by higher urea levels.
format Online
Article
Text
id pubmed-7146188
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71461882020-04-15 Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition Monzani, Alice Crespi, Ilaria Genoni, Giulia Edefonti, Alberto Montini, Giovanni Bellomo, Giorgio Ferrero, Federica Bellone, Simonetta Prodam, Flavia Nutrients Article Background: Kidney function in preterm newborns may be impaired by many factors. Methods: 71 newborns with gestational age (GA) < 32 weeks were enrolled. Serum creatinine (sCr), cystatin C (CysC), beta-trace protein (BTP) and urea were measured at T0 (3rd day of life) and T36 (GA 36 weeks), and estimated glomerular filtration rate (eGFR) was calculated according to different formulas at T36. Pre-natal and post-natal kidney injury risk scores were calculated. Results: Newborns with GA ≤ 28 weeks had higher sCr at T0, and lower sCr, BTP and higher urea levels at T36 (p = 0.007, p = 0.005 and p = 0.029, respectively). eGFR values were not different according to GA when calculated by the formulas using only CysC, but were higher in subjects with GA ≤ 28 weeks according to the other formulas. The post-natal score was positively correlated with eGFR according to sCr-based formulas, but the correlations did not persist when adjusted for urea levels and GA. Conclusions: CysC-based eGFR values are not influenced by GA. Post-natal score shows a direct correlation with eGFR according to sCr-based formulas, not persisting after adjustment for GA and urea levels, implying the importance of the nutritional status, since more premature subjects receive a more aggressive nutritional regimen, testified by higher urea levels. MDPI 2020-02-28 /pmc/articles/PMC7146188/ /pubmed/32121201 http://dx.doi.org/10.3390/nu12030651 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Monzani, Alice
Crespi, Ilaria
Genoni, Giulia
Edefonti, Alberto
Montini, Giovanni
Bellomo, Giorgio
Ferrero, Federica
Bellone, Simonetta
Prodam, Flavia
Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition
title Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition
title_full Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition
title_fullStr Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition
title_full_unstemmed Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition
title_short Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition
title_sort kidney-detrimental factors and estimated glomerular filtration rate in preterm newborns: the role of nutrition
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146188/
https://www.ncbi.nlm.nih.gov/pubmed/32121201
http://dx.doi.org/10.3390/nu12030651
work_keys_str_mv AT monzanialice kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT crespiilaria kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT genonigiulia kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT edefontialberto kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT montinigiovanni kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT bellomogiorgio kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT ferrerofederica kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT bellonesimonetta kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition
AT prodamflavia kidneydetrimentalfactorsandestimatedglomerularfiltrationrateinpretermnewbornstheroleofnutrition