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AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications
This paper presents a capacitive differential bridge structure with both AC and DC excitation and balancing capability for low cost electrode-solution interfacial capacitance biosensing applications. The proposed series RC balancing structure offers higher sensitivity, lower susceptibility to common...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146243/ https://www.ncbi.nlm.nih.gov/pubmed/32235710 http://dx.doi.org/10.3390/bios10030028 |
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author | Neshani, Sara Nyamekye, Charles K. A. Melvin, Scott Smith, Emily A. Chen, Degang J. Neihart, Nathan M. |
author_facet | Neshani, Sara Nyamekye, Charles K. A. Melvin, Scott Smith, Emily A. Chen, Degang J. Neihart, Nathan M. |
author_sort | Neshani, Sara |
collection | PubMed |
description | This paper presents a capacitive differential bridge structure with both AC and DC excitation and balancing capability for low cost electrode-solution interfacial capacitance biosensing applications. The proposed series RC balancing structure offers higher sensitivity, lower susceptibility to common-mode interferences, and drift control. To evaluate the bridge performance in practice, possible effects of initial bridge imbalance due to component mismatches are investigated considering the required resolution of the balancing networks, sensitivity, and linearity. This evaluation is also a guideline to designing the balancing networks, balancing algorithm and the proceeding readout interface circuitry. The proposed series RC bridge structure is implemented along with a custom single frequency real-time amplification/filtering readout board with real-time data acquisition and sine fitting. The main specifications for the implemented structure are 8-bit detection resolution if the total expected fractional capacitance change at the interface is roughly 1%. The characterization and measurement results show the effectiveness of the proposed structure in achieving the design target. The implemented structure successfully achieves distinct detection levels for tiny total capacitance change at the electrode-solution interface, utilizing Microcystin-(Leucine-Arginine) toxin dilutions as a proof of concept. |
format | Online Article Text |
id | pubmed-7146243 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-71462432020-04-15 AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications Neshani, Sara Nyamekye, Charles K. A. Melvin, Scott Smith, Emily A. Chen, Degang J. Neihart, Nathan M. Biosensors (Basel) Article This paper presents a capacitive differential bridge structure with both AC and DC excitation and balancing capability for low cost electrode-solution interfacial capacitance biosensing applications. The proposed series RC balancing structure offers higher sensitivity, lower susceptibility to common-mode interferences, and drift control. To evaluate the bridge performance in practice, possible effects of initial bridge imbalance due to component mismatches are investigated considering the required resolution of the balancing networks, sensitivity, and linearity. This evaluation is also a guideline to designing the balancing networks, balancing algorithm and the proceeding readout interface circuitry. The proposed series RC bridge structure is implemented along with a custom single frequency real-time amplification/filtering readout board with real-time data acquisition and sine fitting. The main specifications for the implemented structure are 8-bit detection resolution if the total expected fractional capacitance change at the interface is roughly 1%. The characterization and measurement results show the effectiveness of the proposed structure in achieving the design target. The implemented structure successfully achieves distinct detection levels for tiny total capacitance change at the electrode-solution interface, utilizing Microcystin-(Leucine-Arginine) toxin dilutions as a proof of concept. MDPI 2020-03-22 /pmc/articles/PMC7146243/ /pubmed/32235710 http://dx.doi.org/10.3390/bios10030028 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Neshani, Sara Nyamekye, Charles K. A. Melvin, Scott Smith, Emily A. Chen, Degang J. Neihart, Nathan M. AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications |
title | AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications |
title_full | AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications |
title_fullStr | AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications |
title_full_unstemmed | AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications |
title_short | AC and DC Differential Bridge Structure Suitable for Electrochemical Interfacial Capacitance Biosensing Applications |
title_sort | ac and dc differential bridge structure suitable for electrochemical interfacial capacitance biosensing applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146243/ https://www.ncbi.nlm.nih.gov/pubmed/32235710 http://dx.doi.org/10.3390/bios10030028 |
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