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Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters

This study investigated the relationship between metabolic parameters and low serum 25-hydroxyvitamin D (25(OH)D) levels in older adults (n = 265). They were assessed for anthropometrics and metabolic measurements, including 25(OH)D, insulin, glucose, total cholesterol (TC), high-density lipoprotein...

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Autores principales: Pott-Junior, Henrique, Nascimento, Carla Manuela Crispim, Costa-Guarisco, Letícia Pimenta, Gomes, Grace Angelica de Oliveira, Gramani-Say, Karina, Orlandi, Fabiana de Souza, Gratão, Aline Cristina Martins, Orlandi, Ariene Angelini dos Santos, Pavarini, Sofia Cristina Iost, Vasilceac, Fernando Augusto, Zazzetta, Marisa Silvana, Cominetti, Marcia Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146307/
https://www.ncbi.nlm.nih.gov/pubmed/32178228
http://dx.doi.org/10.3390/nu12030748
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author Pott-Junior, Henrique
Nascimento, Carla Manuela Crispim
Costa-Guarisco, Letícia Pimenta
Gomes, Grace Angelica de Oliveira
Gramani-Say, Karina
Orlandi, Fabiana de Souza
Gratão, Aline Cristina Martins
Orlandi, Ariene Angelini dos Santos
Pavarini, Sofia Cristina Iost
Vasilceac, Fernando Augusto
Zazzetta, Marisa Silvana
Cominetti, Marcia Regina
author_facet Pott-Junior, Henrique
Nascimento, Carla Manuela Crispim
Costa-Guarisco, Letícia Pimenta
Gomes, Grace Angelica de Oliveira
Gramani-Say, Karina
Orlandi, Fabiana de Souza
Gratão, Aline Cristina Martins
Orlandi, Ariene Angelini dos Santos
Pavarini, Sofia Cristina Iost
Vasilceac, Fernando Augusto
Zazzetta, Marisa Silvana
Cominetti, Marcia Regina
author_sort Pott-Junior, Henrique
collection PubMed
description This study investigated the relationship between metabolic parameters and low serum 25-hydroxyvitamin D (25(OH)D) levels in older adults (n = 265). They were assessed for anthropometrics and metabolic measurements, including 25(OH)D, insulin, glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and other inflammatory markers. Vitamin D deficiency was defined as a 25(OH)D level below 50 nmol/L. Comparisons between groups were performed using Wilcoxon–Mann–Whitney or Pearson’s Chi-squared test. A multivariate adjusted Poisson regression was used to model the number of metabolic parameters as a function of a set of explanatory variables. Subjects with 25(OH)D deficiency were predominantly females and presented higher body weight, body mass index, waist circumference, triglycerides and Tumor Necrosis Factor-α (TNF-α), and higher insulin resistance. Metabolic syndrome was also more prevalent among 25(OH)D-deficient subjects. In those without metabolic syndrome, 25(OH)D deficiency was related only to obesity and higher insulin resistance. Female sex, hypertension, higher waist circumference and higher levels of hemoglobin A1C (%), HDL-C, and TG were significantly associated with an increased number of metabolic syndrome parameters after adjusting for covariates, but 25(OH)D was not. The fact that serum 25(OH)D concentration was inversely associated with metabolic syndrome and insulin resistance not only reaffirms the relevance to consider serum 25(OH)D concentration as an influencing factor for insulin resistance, but also the need to actively screen for hypovitaminosis D in all patients with this condition.
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spelling pubmed-71463072020-04-15 Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters Pott-Junior, Henrique Nascimento, Carla Manuela Crispim Costa-Guarisco, Letícia Pimenta Gomes, Grace Angelica de Oliveira Gramani-Say, Karina Orlandi, Fabiana de Souza Gratão, Aline Cristina Martins Orlandi, Ariene Angelini dos Santos Pavarini, Sofia Cristina Iost Vasilceac, Fernando Augusto Zazzetta, Marisa Silvana Cominetti, Marcia Regina Nutrients Article This study investigated the relationship between metabolic parameters and low serum 25-hydroxyvitamin D (25(OH)D) levels in older adults (n = 265). They were assessed for anthropometrics and metabolic measurements, including 25(OH)D, insulin, glucose, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG) and other inflammatory markers. Vitamin D deficiency was defined as a 25(OH)D level below 50 nmol/L. Comparisons between groups were performed using Wilcoxon–Mann–Whitney or Pearson’s Chi-squared test. A multivariate adjusted Poisson regression was used to model the number of metabolic parameters as a function of a set of explanatory variables. Subjects with 25(OH)D deficiency were predominantly females and presented higher body weight, body mass index, waist circumference, triglycerides and Tumor Necrosis Factor-α (TNF-α), and higher insulin resistance. Metabolic syndrome was also more prevalent among 25(OH)D-deficient subjects. In those without metabolic syndrome, 25(OH)D deficiency was related only to obesity and higher insulin resistance. Female sex, hypertension, higher waist circumference and higher levels of hemoglobin A1C (%), HDL-C, and TG were significantly associated with an increased number of metabolic syndrome parameters after adjusting for covariates, but 25(OH)D was not. The fact that serum 25(OH)D concentration was inversely associated with metabolic syndrome and insulin resistance not only reaffirms the relevance to consider serum 25(OH)D concentration as an influencing factor for insulin resistance, but also the need to actively screen for hypovitaminosis D in all patients with this condition. MDPI 2020-03-12 /pmc/articles/PMC7146307/ /pubmed/32178228 http://dx.doi.org/10.3390/nu12030748 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pott-Junior, Henrique
Nascimento, Carla Manuela Crispim
Costa-Guarisco, Letícia Pimenta
Gomes, Grace Angelica de Oliveira
Gramani-Say, Karina
Orlandi, Fabiana de Souza
Gratão, Aline Cristina Martins
Orlandi, Ariene Angelini dos Santos
Pavarini, Sofia Cristina Iost
Vasilceac, Fernando Augusto
Zazzetta, Marisa Silvana
Cominetti, Marcia Regina
Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
title Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
title_full Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
title_fullStr Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
title_full_unstemmed Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
title_short Vitamin D Deficient Older Adults Are More Prone to Have Metabolic Syndrome, but Not to a Greater Number of Metabolic Syndrome Parameters
title_sort vitamin d deficient older adults are more prone to have metabolic syndrome, but not to a greater number of metabolic syndrome parameters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146307/
https://www.ncbi.nlm.nih.gov/pubmed/32178228
http://dx.doi.org/10.3390/nu12030748
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