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Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention

Aim: This 18 month intervention study aims to determine the efficacy of a lifestyle modification program on prediabetes reversal among Saudi adults. Methods: An 18 month randomized, multicenter trial was conducted among Saudis with prediabetes aged 25–60 recruited from King Salman Hospital and prima...

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Autores principales: Amer, Osama E., Sabico, Shaun, Alfawaz, Hanan A., Aljohani, Naji, Hussain, Syed Danish, Alnaami, Abdullah M., Wani, Kaiser, Al-Daghri, Nasser M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146361/
https://www.ncbi.nlm.nih.gov/pubmed/32197404
http://dx.doi.org/10.3390/nu12030804
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author Amer, Osama E.
Sabico, Shaun
Alfawaz, Hanan A.
Aljohani, Naji
Hussain, Syed Danish
Alnaami, Abdullah M.
Wani, Kaiser
Al-Daghri, Nasser M.
author_facet Amer, Osama E.
Sabico, Shaun
Alfawaz, Hanan A.
Aljohani, Naji
Hussain, Syed Danish
Alnaami, Abdullah M.
Wani, Kaiser
Al-Daghri, Nasser M.
author_sort Amer, Osama E.
collection PubMed
description Aim: This 18 month intervention study aims to determine the efficacy of a lifestyle modification program on prediabetes reversal among Saudi adults. Methods: An 18 month randomized, multicenter trial was conducted among Saudis with prediabetes aged 25–60 recruited from King Salman Hospital and primary care centers in Riyadh, Saudi Arabia. A total of 180 consenting individuals were randomized (1:1) to receive either intensive lifestyle intervention (ILIG) or guidance (control group, CG). ILIG was provided with a personalized lifestyle counseling by nutritionists every 3 months to improve diet and exercise behaviors. CG was given booklets containing information on prediabetes and its prevention. Data from lifestyle assessments and laboratory measurements were analyzed at baseline and every 6 months. The primary outcome was the reversal rate of prediabetes. Results: 158 participants were analyzed (CG:85, ILIG:73) at the 12 month follow-up and 28 participants (CG:11 and ILIG:17) completed the entire 18 month study. Post-intervention, the cumulative incidence of prediabetes reversal in the ILIG was 38 participants (52.1%) which was significantly higher than CG with 26 participants (30.6%) (p = 0.02). Conclusion: A tailored lifestyle intervention is effective in reversing prediabetes, at least for a year, among Arab adults with prediabetes. The challenge of sustaining interest in adopting lifestyle changes for a longer duration should be addressed in this population.
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spelling pubmed-71463612020-04-15 Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention Amer, Osama E. Sabico, Shaun Alfawaz, Hanan A. Aljohani, Naji Hussain, Syed Danish Alnaami, Abdullah M. Wani, Kaiser Al-Daghri, Nasser M. Nutrients Article Aim: This 18 month intervention study aims to determine the efficacy of a lifestyle modification program on prediabetes reversal among Saudi adults. Methods: An 18 month randomized, multicenter trial was conducted among Saudis with prediabetes aged 25–60 recruited from King Salman Hospital and primary care centers in Riyadh, Saudi Arabia. A total of 180 consenting individuals were randomized (1:1) to receive either intensive lifestyle intervention (ILIG) or guidance (control group, CG). ILIG was provided with a personalized lifestyle counseling by nutritionists every 3 months to improve diet and exercise behaviors. CG was given booklets containing information on prediabetes and its prevention. Data from lifestyle assessments and laboratory measurements were analyzed at baseline and every 6 months. The primary outcome was the reversal rate of prediabetes. Results: 158 participants were analyzed (CG:85, ILIG:73) at the 12 month follow-up and 28 participants (CG:11 and ILIG:17) completed the entire 18 month study. Post-intervention, the cumulative incidence of prediabetes reversal in the ILIG was 38 participants (52.1%) which was significantly higher than CG with 26 participants (30.6%) (p = 0.02). Conclusion: A tailored lifestyle intervention is effective in reversing prediabetes, at least for a year, among Arab adults with prediabetes. The challenge of sustaining interest in adopting lifestyle changes for a longer duration should be addressed in this population. MDPI 2020-03-18 /pmc/articles/PMC7146361/ /pubmed/32197404 http://dx.doi.org/10.3390/nu12030804 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Amer, Osama E.
Sabico, Shaun
Alfawaz, Hanan A.
Aljohani, Naji
Hussain, Syed Danish
Alnaami, Abdullah M.
Wani, Kaiser
Al-Daghri, Nasser M.
Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention
title Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention
title_full Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention
title_fullStr Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention
title_full_unstemmed Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention
title_short Reversal of Prediabetes in Saudi Adults: Results from an 18 Month Lifestyle Intervention
title_sort reversal of prediabetes in saudi adults: results from an 18 month lifestyle intervention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146361/
https://www.ncbi.nlm.nih.gov/pubmed/32197404
http://dx.doi.org/10.3390/nu12030804
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