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Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer

Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial...

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Autores principales: Cueva, Carolina, Silva, Mariana, Pinillos, Iris, Bartolomé, Begoña, Moreno-Arribas, M. Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146370/
https://www.ncbi.nlm.nih.gov/pubmed/32120799
http://dx.doi.org/10.3390/nu12030625
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author Cueva, Carolina
Silva, Mariana
Pinillos, Iris
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
author_facet Cueva, Carolina
Silva, Mariana
Pinillos, Iris
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
author_sort Cueva, Carolina
collection PubMed
description Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial composition and a notably higher abundance of putative oral bacteria in colonic tumors. Many experimental studies and preclinical evidence propose that dietary polyphenols have a relevant role in CRC development and progression, mainly attributed to their immunomodulatory activities. Furthermore, polyphenols can modulate oral and gut microbiota, and in turn, intestinal microbes catabolize polyphenols to release metabolites that are often more active and better absorbed than the original phenolic compounds. The current study aimed to review and summarize current knowledge on the role of microbiota and the interactions between dietary polyphenols and microbiota in relation to CRC development. We have highlighted the mechanisms by which dietary polyphenols and/or their microbial metabolites exert their action on the pathogenesis and prevention of CRC as modulators of the composition and/or activity of oral and intestinal microbiota, including novel screening biomarkers and possible nutritional therapeutic implications.
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spelling pubmed-71463702020-04-15 Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer Cueva, Carolina Silva, Mariana Pinillos, Iris Bartolomé, Begoña Moreno-Arribas, M. Victoria Nutrients Review Colorectal cancer (CRC) is the third most diagnosed type of cancer worldwide. Dietary features play an important role in its development, and the involvement of human microbial communities in this pathology has also recently been recognized. Individuals with CRC display alterations in gut bacterial composition and a notably higher abundance of putative oral bacteria in colonic tumors. Many experimental studies and preclinical evidence propose that dietary polyphenols have a relevant role in CRC development and progression, mainly attributed to their immunomodulatory activities. Furthermore, polyphenols can modulate oral and gut microbiota, and in turn, intestinal microbes catabolize polyphenols to release metabolites that are often more active and better absorbed than the original phenolic compounds. The current study aimed to review and summarize current knowledge on the role of microbiota and the interactions between dietary polyphenols and microbiota in relation to CRC development. We have highlighted the mechanisms by which dietary polyphenols and/or their microbial metabolites exert their action on the pathogenesis and prevention of CRC as modulators of the composition and/or activity of oral and intestinal microbiota, including novel screening biomarkers and possible nutritional therapeutic implications. MDPI 2020-02-27 /pmc/articles/PMC7146370/ /pubmed/32120799 http://dx.doi.org/10.3390/nu12030625 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cueva, Carolina
Silva, Mariana
Pinillos, Iris
Bartolomé, Begoña
Moreno-Arribas, M. Victoria
Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer
title Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer
title_full Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer
title_fullStr Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer
title_full_unstemmed Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer
title_short Interplay between Dietary Polyphenols and Oral and Gut Microbiota in the Development of Colorectal Cancer
title_sort interplay between dietary polyphenols and oral and gut microbiota in the development of colorectal cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146370/
https://www.ncbi.nlm.nih.gov/pubmed/32120799
http://dx.doi.org/10.3390/nu12030625
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