Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases

Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin...

Descripción completa

Detalles Bibliográficos
Autores principales: Latacz, Maria, Snarska, Jadwiga, Kostyra, Elżbieta, Fiedorowicz, Ewa, Savelkoul, Huub F. J., Grzybowski, Roman, Cieślińska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146376/
https://www.ncbi.nlm.nih.gov/pubmed/32197412
http://dx.doi.org/10.3390/nu12030801
_version_ 1783520186972766208
author Latacz, Maria
Snarska, Jadwiga
Kostyra, Elżbieta
Fiedorowicz, Ewa
Savelkoul, Huub F. J.
Grzybowski, Roman
Cieślińska, Anna
author_facet Latacz, Maria
Snarska, Jadwiga
Kostyra, Elżbieta
Fiedorowicz, Ewa
Savelkoul, Huub F. J.
Grzybowski, Roman
Cieślińska, Anna
author_sort Latacz, Maria
collection PubMed
description Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in CYP27B1 gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin’s lymphoma, oral lichen planus, or multiple sclerosis.
format Online
Article
Text
id pubmed-7146376
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71463762020-04-15 Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases Latacz, Maria Snarska, Jadwiga Kostyra, Elżbieta Fiedorowicz, Ewa Savelkoul, Huub F. J. Grzybowski, Roman Cieślińska, Anna Nutrients Review Vitamin D is widely known for its roles in the promotion of apoptosis and differentiation, with simultaneous inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis. Modern literature lacks complete information on polymorphisms in CYP27B1, the only enzyme capable of vitamin D activation. This review presents gathered data that relate to genetic variants in CYP27B1 gene in correlation to multiple diseases, mostly concerning colorectal, prostate, breast, lung, and pancreatic cancers, as well as on other pathologies, such as non-Hodgkin’s lymphoma, oral lichen planus, or multiple sclerosis. MDPI 2020-03-18 /pmc/articles/PMC7146376/ /pubmed/32197412 http://dx.doi.org/10.3390/nu12030801 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Latacz, Maria
Snarska, Jadwiga
Kostyra, Elżbieta
Fiedorowicz, Ewa
Savelkoul, Huub F. J.
Grzybowski, Roman
Cieślińska, Anna
Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases
title Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases
title_full Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases
title_fullStr Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases
title_full_unstemmed Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases
title_short Single Nucleotide Polymorphisms in 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase (CYP27B1) Gene: The Risk of Malignant Tumors and Other Chronic Diseases
title_sort single nucleotide polymorphisms in 25-hydroxyvitamin d3 1-alpha-hydroxylase (cyp27b1) gene: the risk of malignant tumors and other chronic diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146376/
https://www.ncbi.nlm.nih.gov/pubmed/32197412
http://dx.doi.org/10.3390/nu12030801
work_keys_str_mv AT lataczmaria singlenucleotidepolymorphismsin25hydroxyvitamind31alphahydroxylasecyp27b1genetheriskofmalignanttumorsandotherchronicdiseases
AT snarskajadwiga singlenucleotidepolymorphismsin25hydroxyvitamind31alphahydroxylasecyp27b1genetheriskofmalignanttumorsandotherchronicdiseases
AT kostyraelzbieta singlenucleotidepolymorphismsin25hydroxyvitamind31alphahydroxylasecyp27b1genetheriskofmalignanttumorsandotherchronicdiseases
AT fiedorowiczewa singlenucleotidepolymorphismsin25hydroxyvitamind31alphahydroxylasecyp27b1genetheriskofmalignanttumorsandotherchronicdiseases
AT savelkoulhuubfj singlenucleotidepolymorphismsin25hydroxyvitamind31alphahydroxylasecyp27b1genetheriskofmalignanttumorsandotherchronicdiseases
AT grzybowskiroman singlenucleotidepolymorphismsin25hydroxyvitamind31alphahydroxylasecyp27b1genetheriskofmalignanttumorsandotherchronicdiseases
AT cieslinskaanna singlenucleotidepolymorphismsin25hydroxyvitamind31alphahydroxylasecyp27b1genetheriskofmalignanttumorsandotherchronicdiseases

Ejemplares similares