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Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study

Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate...

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Autores principales: Müller, Sandra M., Dawczynski, Christine, Wiest, Johanna, Lorkowski, Stefan, Kipp, Anna P., Schwerdtle, Tanja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146433/
https://www.ncbi.nlm.nih.gov/pubmed/32131476
http://dx.doi.org/10.3390/nu12030676
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author Müller, Sandra M.
Dawczynski, Christine
Wiest, Johanna
Lorkowski, Stefan
Kipp, Anna P.
Schwerdtle, Tanja
author_facet Müller, Sandra M.
Dawczynski, Christine
Wiest, Johanna
Lorkowski, Stefan
Kipp, Anna P.
Schwerdtle, Tanja
author_sort Müller, Sandra M.
collection PubMed
description Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate that low selenium serum concentrations could be related to cardiovascular diseases. Inter alia, risk factors for cardiovascular diseases are physical inactivity, overweight, as well as disadvantageous eating habits. In order to assess whether these risk factors can be modulated, a cardio-protective diet comprising fixed menu plans combined with physical exercise was applied in the German MoKaRi (modulation of cardiovascular risk factors) intervention study. We analyzed serum samples of the MoKaRi cohort (51 participants) for total selenium, GPx activity, and selenoprotein P at different timepoints of the study (0, 10, 20, 40 weeks) to explore the suitability of these selenium-associated markers as indicators of selenium status. Overall, the time-dependent fluctuations in serum selenium concentration suggest a successful change in nutritional and lifestyle behavior. Compared to baseline, a pronounced increase in GPx activity and selenoprotein P was observed, while serum selenium decreased in participants with initially adequate serum selenium content. SELENOP concentration showed a moderate positive monotonic correlation (r = 0.467, p < 0.0001) to total Se concentration, while only a weak linear relationship was observed for GPx activity versus total Se concentration (r = 0.186, p = 0.021). Evidently, other factors apart from the available Se pool must have an impact on the GPx activity, leading to the conclusion that, without having identified these factors, GPx activity should not be used as a status marker for Se.
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spelling pubmed-71464332020-04-15 Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study Müller, Sandra M. Dawczynski, Christine Wiest, Johanna Lorkowski, Stefan Kipp, Anna P. Schwerdtle, Tanja Nutrients Article Soils in Germany are commonly low in selenium; consequently, a sufficient dietary supply is not always ensured. The extent of such provision adequacy is estimated by the optimal effect range of biomarkers, which often reflects the physiological requirement. Preceding epidemiological studies indicate that low selenium serum concentrations could be related to cardiovascular diseases. Inter alia, risk factors for cardiovascular diseases are physical inactivity, overweight, as well as disadvantageous eating habits. In order to assess whether these risk factors can be modulated, a cardio-protective diet comprising fixed menu plans combined with physical exercise was applied in the German MoKaRi (modulation of cardiovascular risk factors) intervention study. We analyzed serum samples of the MoKaRi cohort (51 participants) for total selenium, GPx activity, and selenoprotein P at different timepoints of the study (0, 10, 20, 40 weeks) to explore the suitability of these selenium-associated markers as indicators of selenium status. Overall, the time-dependent fluctuations in serum selenium concentration suggest a successful change in nutritional and lifestyle behavior. Compared to baseline, a pronounced increase in GPx activity and selenoprotein P was observed, while serum selenium decreased in participants with initially adequate serum selenium content. SELENOP concentration showed a moderate positive monotonic correlation (r = 0.467, p < 0.0001) to total Se concentration, while only a weak linear relationship was observed for GPx activity versus total Se concentration (r = 0.186, p = 0.021). Evidently, other factors apart from the available Se pool must have an impact on the GPx activity, leading to the conclusion that, without having identified these factors, GPx activity should not be used as a status marker for Se. MDPI 2020-03-02 /pmc/articles/PMC7146433/ /pubmed/32131476 http://dx.doi.org/10.3390/nu12030676 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Müller, Sandra M.
Dawczynski, Christine
Wiest, Johanna
Lorkowski, Stefan
Kipp, Anna P.
Schwerdtle, Tanja
Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
title Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
title_full Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
title_fullStr Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
title_full_unstemmed Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
title_short Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study
title_sort functional biomarkers for the selenium status in a human nutritional intervention study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146433/
https://www.ncbi.nlm.nih.gov/pubmed/32131476
http://dx.doi.org/10.3390/nu12030676
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