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Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry

Few studies have evaluated the role of methylation-pathway nutrients involved in fetal growth (B vitamins, choline, betaine, and methionine). These one-carbon metabolism (OCM) nutrients are essential for DNA methylation in the periconception period. We aimed to characterize dietary patterns of 1638...

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Autores principales: Lecorguillé, Marion, Lioret, Sandrine, de Lauzon-Guillain, Blandine, de Gavelle, Erwan, Forhan, Anne, Mariotti, François, Charles, Marie-Aline, Heude, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146458/
https://www.ncbi.nlm.nih.gov/pubmed/32245126
http://dx.doi.org/10.3390/nu12030838
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author Lecorguillé, Marion
Lioret, Sandrine
de Lauzon-Guillain, Blandine
de Gavelle, Erwan
Forhan, Anne
Mariotti, François
Charles, Marie-Aline
Heude, Barbara
author_facet Lecorguillé, Marion
Lioret, Sandrine
de Lauzon-Guillain, Blandine
de Gavelle, Erwan
Forhan, Anne
Mariotti, François
Charles, Marie-Aline
Heude, Barbara
author_sort Lecorguillé, Marion
collection PubMed
description Few studies have evaluated the role of methylation-pathway nutrients involved in fetal growth (B vitamins, choline, betaine, and methionine). These one-carbon metabolism (OCM) nutrients are essential for DNA methylation in the periconception period. We aimed to characterize dietary patterns of 1638 women from the EDEN mother-child cohort in the year before pregnancy according to the contribution of OCM nutrients and to study the association of such patterns with anthropometric measurements at birth. Dietary intake before pregnancy was assessed by using a semi-quantitative food frequency questionnaire. We used the reduced-rank regression (RRR) method to identify dietary patterns using OCM nutrients as intermediate variables. We ran linear regressions models to study the association between dietary patterns scores and birth weight, length, head circumference, gestational age, and sex-specific z-scores, adjusting for maternal characteristics and vitamin supplementation before and during pregnancy. Three patterns, “varied and balanced”, “vegetarian tendency”, and “bread and starchy food” were identified, explaining 58% of the variability in OCM nutrient intake. Higher scores on the “varied and balanced” pattern tended to be associated with higher birth length and weight. In mainly well-nourished young French women, we did not find evidence that variability in OCM nutrient intake has major effects on fetal growth.
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spelling pubmed-71464582020-04-15 Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry Lecorguillé, Marion Lioret, Sandrine de Lauzon-Guillain, Blandine de Gavelle, Erwan Forhan, Anne Mariotti, François Charles, Marie-Aline Heude, Barbara Nutrients Article Few studies have evaluated the role of methylation-pathway nutrients involved in fetal growth (B vitamins, choline, betaine, and methionine). These one-carbon metabolism (OCM) nutrients are essential for DNA methylation in the periconception period. We aimed to characterize dietary patterns of 1638 women from the EDEN mother-child cohort in the year before pregnancy according to the contribution of OCM nutrients and to study the association of such patterns with anthropometric measurements at birth. Dietary intake before pregnancy was assessed by using a semi-quantitative food frequency questionnaire. We used the reduced-rank regression (RRR) method to identify dietary patterns using OCM nutrients as intermediate variables. We ran linear regressions models to study the association between dietary patterns scores and birth weight, length, head circumference, gestational age, and sex-specific z-scores, adjusting for maternal characteristics and vitamin supplementation before and during pregnancy. Three patterns, “varied and balanced”, “vegetarian tendency”, and “bread and starchy food” were identified, explaining 58% of the variability in OCM nutrient intake. Higher scores on the “varied and balanced” pattern tended to be associated with higher birth length and weight. In mainly well-nourished young French women, we did not find evidence that variability in OCM nutrient intake has major effects on fetal growth. MDPI 2020-03-20 /pmc/articles/PMC7146458/ /pubmed/32245126 http://dx.doi.org/10.3390/nu12030838 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lecorguillé, Marion
Lioret, Sandrine
de Lauzon-Guillain, Blandine
de Gavelle, Erwan
Forhan, Anne
Mariotti, François
Charles, Marie-Aline
Heude, Barbara
Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry
title Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry
title_full Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry
title_fullStr Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry
title_full_unstemmed Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry
title_short Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry
title_sort association between dietary intake of one-carbon metabolism nutrients in the year before pregnancy and birth anthropometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146458/
https://www.ncbi.nlm.nih.gov/pubmed/32245126
http://dx.doi.org/10.3390/nu12030838
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