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Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk f...

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Autores principales: Hernandez-Baixauli, Julia, Quesada-Vázquez, Sergio, Mariné-Casadó, Roger, Gil Cardoso, Katherine, Caimari, Antoni, Del Bas, Josep M, Escoté, Xavier, Baselga-Escudero, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146483/
https://www.ncbi.nlm.nih.gov/pubmed/32197513
http://dx.doi.org/10.3390/nu12030806
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author Hernandez-Baixauli, Julia
Quesada-Vázquez, Sergio
Mariné-Casadó, Roger
Gil Cardoso, Katherine
Caimari, Antoni
Del Bas, Josep M
Escoté, Xavier
Baselga-Escudero, Laura
author_facet Hernandez-Baixauli, Julia
Quesada-Vázquez, Sergio
Mariné-Casadó, Roger
Gil Cardoso, Katherine
Caimari, Antoni
Del Bas, Josep M
Escoté, Xavier
Baselga-Escudero, Laura
author_sort Hernandez-Baixauli, Julia
collection PubMed
description The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not been enough precise to detect the primary stages of disease. Thus, there is a need to obtain novel molecular markers of pre-disease stages. A promising source of new molecular markers are metabolomics standing out the research of biomarkers in NMR approaches. An increasing number of nutritionists integrate metabolomics into their study design, making nutrimetabolomics one of the most promising avenues for improving personalized nutrition. This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis. Together, it is proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for these patients.
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spelling pubmed-71464832020-04-20 Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment Hernandez-Baixauli, Julia Quesada-Vázquez, Sergio Mariné-Casadó, Roger Gil Cardoso, Katherine Caimari, Antoni Del Bas, Josep M Escoté, Xavier Baselga-Escudero, Laura Nutrients Review The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not been enough precise to detect the primary stages of disease. Thus, there is a need to obtain novel molecular markers of pre-disease stages. A promising source of new molecular markers are metabolomics standing out the research of biomarkers in NMR approaches. An increasing number of nutritionists integrate metabolomics into their study design, making nutrimetabolomics one of the most promising avenues for improving personalized nutrition. This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis. Together, it is proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for these patients. MDPI 2020-03-18 /pmc/articles/PMC7146483/ /pubmed/32197513 http://dx.doi.org/10.3390/nu12030806 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hernandez-Baixauli, Julia
Quesada-Vázquez, Sergio
Mariné-Casadó, Roger
Gil Cardoso, Katherine
Caimari, Antoni
Del Bas, Josep M
Escoté, Xavier
Baselga-Escudero, Laura
Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
title Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
title_full Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
title_fullStr Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
title_full_unstemmed Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
title_short Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment
title_sort detection of early disease risk factors associated with metabolic syndrome: a new era with the nmr metabolomics assessment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146483/
https://www.ncbi.nlm.nih.gov/pubmed/32197513
http://dx.doi.org/10.3390/nu12030806
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