Cargando…

Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer

Over the past decades, survival rates for patients with resectable esophageal cancer have improved significantly. Consequently, the sequelae of having a gastric conduit, such as development of micronutrient deficiencies, become increasingly apparent. This study investigated postoperative micronutrie...

Descripción completa

Detalles Bibliográficos
Autores principales: Janssen, Henricus J.B., Fransen, Laura F.C., Ponten, Jeroen E.H., Nieuwenhuijzen, Grard A.P., Luyer, Misha D.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146612/
https://www.ncbi.nlm.nih.gov/pubmed/32183492
http://dx.doi.org/10.3390/nu12030778
_version_ 1783520241315217408
author Janssen, Henricus J.B.
Fransen, Laura F.C.
Ponten, Jeroen E.H.
Nieuwenhuijzen, Grard A.P.
Luyer, Misha D.P.
author_facet Janssen, Henricus J.B.
Fransen, Laura F.C.
Ponten, Jeroen E.H.
Nieuwenhuijzen, Grard A.P.
Luyer, Misha D.P.
author_sort Janssen, Henricus J.B.
collection PubMed
description Over the past decades, survival rates for patients with resectable esophageal cancer have improved significantly. Consequently, the sequelae of having a gastric conduit, such as development of micronutrient deficiencies, become increasingly apparent. This study investigated postoperative micronutrient trends in the follow-up of patients following a minimally invasive esophagectomy (MIE) for cancer. Patients were included if they had at least one postoperative evaluation of iron, ferritin, vitamins B1, B6, B12, D, folate or methylmalonic acid. Data were available in 83 of 95 patients. Of these, 78.3% (65/83) had at least one and 37.3% (31/83) had more than one micronutrient deficiency at a median of 6.1 months (interquartile range (IQR) 5.4–7.5) of follow-up. Similar to the results found in previous studies, most common deficiencies identified were: iron, vitamin B12 and vitamin D. In addition, folate deficiency and anemia were detected in a substantial amount of patients in this cohort. At 24.8 months (IQR 19.4–33.1) of follow-up, micronutrient deficiencies were still common, however, most deficiencies normalized following supplementation on indication. In conclusion, patients undergoing a MIE are at risk of developing micronutrient deficiencies as early as 6 up to 24 months after surgery and should therefore be routinely checked and supplemented when needed.
format Online
Article
Text
id pubmed-7146612
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71466122020-04-20 Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer Janssen, Henricus J.B. Fransen, Laura F.C. Ponten, Jeroen E.H. Nieuwenhuijzen, Grard A.P. Luyer, Misha D.P. Nutrients Article Over the past decades, survival rates for patients with resectable esophageal cancer have improved significantly. Consequently, the sequelae of having a gastric conduit, such as development of micronutrient deficiencies, become increasingly apparent. This study investigated postoperative micronutrient trends in the follow-up of patients following a minimally invasive esophagectomy (MIE) for cancer. Patients were included if they had at least one postoperative evaluation of iron, ferritin, vitamins B1, B6, B12, D, folate or methylmalonic acid. Data were available in 83 of 95 patients. Of these, 78.3% (65/83) had at least one and 37.3% (31/83) had more than one micronutrient deficiency at a median of 6.1 months (interquartile range (IQR) 5.4–7.5) of follow-up. Similar to the results found in previous studies, most common deficiencies identified were: iron, vitamin B12 and vitamin D. In addition, folate deficiency and anemia were detected in a substantial amount of patients in this cohort. At 24.8 months (IQR 19.4–33.1) of follow-up, micronutrient deficiencies were still common, however, most deficiencies normalized following supplementation on indication. In conclusion, patients undergoing a MIE are at risk of developing micronutrient deficiencies as early as 6 up to 24 months after surgery and should therefore be routinely checked and supplemented when needed. MDPI 2020-03-15 /pmc/articles/PMC7146612/ /pubmed/32183492 http://dx.doi.org/10.3390/nu12030778 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Janssen, Henricus J.B.
Fransen, Laura F.C.
Ponten, Jeroen E.H.
Nieuwenhuijzen, Grard A.P.
Luyer, Misha D.P.
Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer
title Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer
title_full Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer
title_fullStr Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer
title_full_unstemmed Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer
title_short Micronutrient Deficiencies Following Minimally Invasive Esophagectomy for Cancer
title_sort micronutrient deficiencies following minimally invasive esophagectomy for cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146612/
https://www.ncbi.nlm.nih.gov/pubmed/32183492
http://dx.doi.org/10.3390/nu12030778
work_keys_str_mv AT janssenhenricusjb micronutrientdeficienciesfollowingminimallyinvasiveesophagectomyforcancer
AT fransenlaurafc micronutrientdeficienciesfollowingminimallyinvasiveesophagectomyforcancer
AT pontenjeroeneh micronutrientdeficienciesfollowingminimallyinvasiveesophagectomyforcancer
AT nieuwenhuijzengrardap micronutrientdeficienciesfollowingminimallyinvasiveesophagectomyforcancer
AT luyermishadp micronutrientdeficienciesfollowingminimallyinvasiveesophagectomyforcancer