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European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds

A great variety of functional foods, nutraceuticals, or foods with bioactive compounds are provided nowadays to consumers. Aware of the importance of the safety aspects, the food industry has to comply with different legal requirements around the world. In this review, the European regulatory framew...

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Autores principales: Vettorazzi, Ariane, López de Cerain, Adela, Sanz-Serrano, Julen, Gil, Ana G., Azqueta, Amaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146632/
https://www.ncbi.nlm.nih.gov/pubmed/32110982
http://dx.doi.org/10.3390/nu12030613
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author Vettorazzi, Ariane
López de Cerain, Adela
Sanz-Serrano, Julen
Gil, Ana G.
Azqueta, Amaya
author_facet Vettorazzi, Ariane
López de Cerain, Adela
Sanz-Serrano, Julen
Gil, Ana G.
Azqueta, Amaya
author_sort Vettorazzi, Ariane
collection PubMed
description A great variety of functional foods, nutraceuticals, or foods with bioactive compounds are provided nowadays to consumers. Aware of the importance of the safety aspects, the food industry has to comply with different legal requirements around the world. In this review, the European regulatory framework for food-related bioactive compounds is summarized. The term ‘bioactive compound’ is not defined in the European regulations, however, since they can be part of food supplements, fortified foods, or novel food, they are included within the legal requirements of those corresponding types of foods or supplements. Lists of authorized compounds/foods appear in the correspondent regulations, however, when a new compound/food is going to be launched into the market, its safety assessment is essential. Although the responsibility for the safety of these compounds/foods lies with the food business operator placing the product on the market, the European Food Safety Authority (EFSA) carries out scientific evaluations to assess the risks for human health. To facilitate this procedure, different guidelines exist at the European level to explain the tier toxicity testing approach to be considered. This approach divides the evaluation into four areas: (a) toxicokinetics; (b) genotoxicity; (c) subchronic and chronic toxicity and carcinogenicity; and (d) reproductive and developmental toxicity.
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spelling pubmed-71466322020-04-20 European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds Vettorazzi, Ariane López de Cerain, Adela Sanz-Serrano, Julen Gil, Ana G. Azqueta, Amaya Nutrients Review A great variety of functional foods, nutraceuticals, or foods with bioactive compounds are provided nowadays to consumers. Aware of the importance of the safety aspects, the food industry has to comply with different legal requirements around the world. In this review, the European regulatory framework for food-related bioactive compounds is summarized. The term ‘bioactive compound’ is not defined in the European regulations, however, since they can be part of food supplements, fortified foods, or novel food, they are included within the legal requirements of those corresponding types of foods or supplements. Lists of authorized compounds/foods appear in the correspondent regulations, however, when a new compound/food is going to be launched into the market, its safety assessment is essential. Although the responsibility for the safety of these compounds/foods lies with the food business operator placing the product on the market, the European Food Safety Authority (EFSA) carries out scientific evaluations to assess the risks for human health. To facilitate this procedure, different guidelines exist at the European level to explain the tier toxicity testing approach to be considered. This approach divides the evaluation into four areas: (a) toxicokinetics; (b) genotoxicity; (c) subchronic and chronic toxicity and carcinogenicity; and (d) reproductive and developmental toxicity. MDPI 2020-02-26 /pmc/articles/PMC7146632/ /pubmed/32110982 http://dx.doi.org/10.3390/nu12030613 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vettorazzi, Ariane
López de Cerain, Adela
Sanz-Serrano, Julen
Gil, Ana G.
Azqueta, Amaya
European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds
title European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds
title_full European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds
title_fullStr European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds
title_full_unstemmed European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds
title_short European Regulatory Framework and Safety Assessment of Food-Related Bioactive Compounds
title_sort european regulatory framework and safety assessment of food-related bioactive compounds
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146632/
https://www.ncbi.nlm.nih.gov/pubmed/32110982
http://dx.doi.org/10.3390/nu12030613
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