Cargando…

The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria

Several biological markers have been identified as risk factors for cardiovascular disease and are associated with increased risk of metabolic syndrome (MetS). This study provides a factual information on promising biomarkers that are associated with MetS and can aid in early detection and managemen...

Descripción completa

Detalles Bibliográficos
Autores principales: Belhayara, Mohammed Ilyes, Mellouk, Zoheir, Hamdaoui, Mohammed Seddik, Bachaoui, Malika, Kheroua, Omar, Malaisse, Willy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146633/
https://www.ncbi.nlm.nih.gov/pubmed/32164195
http://dx.doi.org/10.3390/nu12030727
_version_ 1783520246192144384
author Belhayara, Mohammed Ilyes
Mellouk, Zoheir
Hamdaoui, Mohammed Seddik
Bachaoui, Malika
Kheroua, Omar
Malaisse, Willy J.
author_facet Belhayara, Mohammed Ilyes
Mellouk, Zoheir
Hamdaoui, Mohammed Seddik
Bachaoui, Malika
Kheroua, Omar
Malaisse, Willy J.
author_sort Belhayara, Mohammed Ilyes
collection PubMed
description Several biological markers have been identified as risk factors for cardiovascular disease and are associated with increased risk of metabolic syndrome (MetS). This study provides a factual information on promising biomarkers that are associated with MetS and can aid in early detection and management of MetS in young adults of Western Algeria. We studied a total of one hundred subjects aged between thirty and forty years with MetS, in which anthropometric measurements, insulin resistance, C peptide and HbA1c, lipid profile, circulating adipokines and glucagon-like peptide-1 were measured by suitable methods, in comparison to two groups of control. MetS is closely linked to altered glucose homeostasis, the plasma insulin/glucose ratio; i.e., the insulinogenic index helps to estimate the level of insulin secretion and also for assessing β-cell function. The correlation between homeostasis model assessment insulin resistance index (HOMA-IR) and HbA1c, body mass index or plasma triglycerides yielded positive and significant values. Biomarkers with a known and predictable association with MetS can provide a means to detect those at risk and intervene as needed. This could significantly decrease the burden complications impose on patients and the healthcare system.
format Online
Article
Text
id pubmed-7146633
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-71466332020-04-20 The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria Belhayara, Mohammed Ilyes Mellouk, Zoheir Hamdaoui, Mohammed Seddik Bachaoui, Malika Kheroua, Omar Malaisse, Willy J. Nutrients Article Several biological markers have been identified as risk factors for cardiovascular disease and are associated with increased risk of metabolic syndrome (MetS). This study provides a factual information on promising biomarkers that are associated with MetS and can aid in early detection and management of MetS in young adults of Western Algeria. We studied a total of one hundred subjects aged between thirty and forty years with MetS, in which anthropometric measurements, insulin resistance, C peptide and HbA1c, lipid profile, circulating adipokines and glucagon-like peptide-1 were measured by suitable methods, in comparison to two groups of control. MetS is closely linked to altered glucose homeostasis, the plasma insulin/glucose ratio; i.e., the insulinogenic index helps to estimate the level of insulin secretion and also for assessing β-cell function. The correlation between homeostasis model assessment insulin resistance index (HOMA-IR) and HbA1c, body mass index or plasma triglycerides yielded positive and significant values. Biomarkers with a known and predictable association with MetS can provide a means to detect those at risk and intervene as needed. This could significantly decrease the burden complications impose on patients and the healthcare system. MDPI 2020-03-10 /pmc/articles/PMC7146633/ /pubmed/32164195 http://dx.doi.org/10.3390/nu12030727 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Belhayara, Mohammed Ilyes
Mellouk, Zoheir
Hamdaoui, Mohammed Seddik
Bachaoui, Malika
Kheroua, Omar
Malaisse, Willy J.
The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria
title The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria
title_full The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria
title_fullStr The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria
title_full_unstemmed The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria
title_short The Metabolic Syndrome: Emerging Novel Insights Regarding the Relationship between the Homeostasis Model Assessment of Insulin Resistance and other Key Predictive Markers in Young Adults of Western Algeria
title_sort metabolic syndrome: emerging novel insights regarding the relationship between the homeostasis model assessment of insulin resistance and other key predictive markers in young adults of western algeria
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146633/
https://www.ncbi.nlm.nih.gov/pubmed/32164195
http://dx.doi.org/10.3390/nu12030727
work_keys_str_mv AT belhayaramohammedilyes themetabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT melloukzoheir themetabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT hamdaouimohammedseddik themetabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT bachaouimalika themetabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT kherouaomar themetabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT malaissewillyj themetabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT belhayaramohammedilyes metabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT melloukzoheir metabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT hamdaouimohammedseddik metabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT bachaouimalika metabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT kherouaomar metabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria
AT malaissewillyj metabolicsyndromeemergingnovelinsightsregardingtherelationshipbetweenthehomeostasismodelassessmentofinsulinresistanceandotherkeypredictivemarkersinyoungadultsofwesternalgeria