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Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis
The Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus related to various types of cancers, including epithelial nasopharyngeal carcinoma, gastric carcinoma, and lymphoma. Long noncoding RNAs (lncRNAs) are expressed extensively in mammalian cells and play crucial roles in regulating various cell...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146903/ https://www.ncbi.nlm.nih.gov/pubmed/32272952 http://dx.doi.org/10.1186/s12985-020-01308-y |
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author | Zhang, Jing Li, Xiaohan Hu, Jingjin Cao, Pengfei Yan, Qijia Zhang, Siwei Dang, Wei Lu, Jianhong |
author_facet | Zhang, Jing Li, Xiaohan Hu, Jingjin Cao, Pengfei Yan, Qijia Zhang, Siwei Dang, Wei Lu, Jianhong |
author_sort | Zhang, Jing |
collection | PubMed |
description | The Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus related to various types of cancers, including epithelial nasopharyngeal carcinoma, gastric carcinoma, and lymphoma. Long noncoding RNAs (lncRNAs) are expressed extensively in mammalian cells and play crucial roles in regulating various cellular processes and multiple cancers. Cellular lncRNAs can be differentially expressed induced by EBV infection. The dysregulated lncRNAs probably modulate the host immune response and other biological functions. At present, lncRNAs have been found to be significantly increased or decreased in EBV-infected cells, exosomes and EBV-associated cancers, suggesting their potential function and clinical application as biomarkers. In addition, EBV-encoded lncRNAs, BART and BHLF1 lncRNAs, may play roles in the viral oncogenesis. Analysis of the specific lncRNAs involved in interactions with the EBV machinery will provide information on their potential mechanism of action during multiple steps of EBV tumorigenesis. Here, we review the current knowledge regarding EBV-related lncRNAs and their possible roles in the pathogenesis of EBV-associated cancers. |
format | Online Article Text |
id | pubmed-7146903 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-71469032020-04-18 Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis Zhang, Jing Li, Xiaohan Hu, Jingjin Cao, Pengfei Yan, Qijia Zhang, Siwei Dang, Wei Lu, Jianhong Virol J Review The Epstein-Barr virus (EBV) is a ubiquitous γ-herpesvirus related to various types of cancers, including epithelial nasopharyngeal carcinoma, gastric carcinoma, and lymphoma. Long noncoding RNAs (lncRNAs) are expressed extensively in mammalian cells and play crucial roles in regulating various cellular processes and multiple cancers. Cellular lncRNAs can be differentially expressed induced by EBV infection. The dysregulated lncRNAs probably modulate the host immune response and other biological functions. At present, lncRNAs have been found to be significantly increased or decreased in EBV-infected cells, exosomes and EBV-associated cancers, suggesting their potential function and clinical application as biomarkers. In addition, EBV-encoded lncRNAs, BART and BHLF1 lncRNAs, may play roles in the viral oncogenesis. Analysis of the specific lncRNAs involved in interactions with the EBV machinery will provide information on their potential mechanism of action during multiple steps of EBV tumorigenesis. Here, we review the current knowledge regarding EBV-related lncRNAs and their possible roles in the pathogenesis of EBV-associated cancers. BioMed Central 2020-04-09 /pmc/articles/PMC7146903/ /pubmed/32272952 http://dx.doi.org/10.1186/s12985-020-01308-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhang, Jing Li, Xiaohan Hu, Jingjin Cao, Pengfei Yan, Qijia Zhang, Siwei Dang, Wei Lu, Jianhong Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis |
title | Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis |
title_full | Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis |
title_fullStr | Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis |
title_full_unstemmed | Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis |
title_short | Long noncoding RNAs involvement in Epstein-Barr virus infection and tumorigenesis |
title_sort | long noncoding rnas involvement in epstein-barr virus infection and tumorigenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7146903/ https://www.ncbi.nlm.nih.gov/pubmed/32272952 http://dx.doi.org/10.1186/s12985-020-01308-y |
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