Inhibition of SYK kinase does not confer a pro-proliferative or pro-invasive phenotype in breast epithelium or breast cancer cells

SYK has been reported to possess both tumour promotor and repressor activities and deletion has been linked to a pro-proliferative / pro-invasive phenotype in breast tumours. It is unclear whether this is a consequence of protein deletion or loss of kinase activity. The SYK inhibitor, BI 1002494, ca...

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Detalles Bibliográficos
Autores principales: Lamb, David J., Rust, Aleksander, Rudisch, Albin, Glüxam, Tobias, Harrer, Nathalie, Machat, Herwig, Christ, Ingrid, Colbatzky, Florian, Wernitznig, Andreas, Osswald, Annika, Sommergruber, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147091/
https://www.ncbi.nlm.nih.gov/pubmed/32292575
http://dx.doi.org/10.18632/oncotarget.27545

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