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Fusion of lysosomes to plasma membrane initiates radiation-induced apoptosis

Diverse stresses, including reactive oxygen species (ROS), ionizing radiation, and chemotherapies, activate acid sphingomyelinase (ASMase) and generate the second messenger ceramide at plasma membranes, triggering apoptosis in specific cells, such as hematopoietic cells and endothelium. Ceramide ele...

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Detalles Bibliográficos
Autores principales:	Ferranti, Charles S., Cheng, Jin, Thompson, Chris, Zhang, Jianjun, Rotolo, Jimmy A., Buddaseth, Salma, Fuks, Zvi, Kolesnick, Richard N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147101/ https://www.ncbi.nlm.nih.gov/pubmed/32328634 http://dx.doi.org/10.1083/jcb.201903176

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