FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells

Fragile-X mental retardation autosomal homologue-1 (FXR1) is a muscle-enriched RNA-binding protein. FXR1 depletion is perinatally lethal in mice, Xenopus, and zebrafish; however, the mechanisms driving these phenotypes remain unclear. The FXR1 gene undergoes alternative splicing, producing multiple...

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Detalles Bibliográficos
Autores principales: Smith, Jean A., Curry, Ennessa G., Blue, R. Eric, Roden, Christine, Dundon, Samantha E.R., Rodríguez-Vargas, Anthony, Jordan, Danielle C., Chen, Xiaomin, Lyons, Shawn M., Crutchley, John, Anderson, Paul, Horb, Marko E., Gladfelter, Amy S., Giudice, Jimena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147106/
https://www.ncbi.nlm.nih.gov/pubmed/32328638
http://dx.doi.org/10.1083/jcb.201911129

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